Efficacy of palonosetron plus dexamethasone in preventing chemotherapy-induced nausea and emesis in patients receiving carboplatin-based chemotherapy for gynecologic cancers: a phase II study by the West Japan Gynecologic Oncology Group (WJGOG 131)

Journal of Gynecologic Oncology
Shin NishioKimio Ushijima

Abstract

Palonosetron is effective for the management of acute and delayed chemotherapy-induced nausea and vomiting (CINV). While emetogenic carboplatin-based chemotherapy is widely used to treat gynecologic cancers, few studies have evaluated the antiemetic effectiveness of palonosetron in this setting. A multicenter, single-arm, open-label phase II trial was conducted to evaluate the safety and effectiveness of palonosetron in controlling CINV in patients with gynecologic cancer. Chemotherapy-naïve patients received intravenous palonosetron (0.75 mg/body) and dexamethasone before the infusion of carboplatin-based chemotherapy on day 1. Dexamethasone was administered (orally or intravenously) on days 2-3. The incidence and severity of CINV were evaluated using the patient-completed Multinational Association of Supportive Care in Cancer Antiemesis Tool and treatment diaries. The primary endpoint was the proportion of patients experiencing complete control (CC) of vomiting, with "no rescue antiemetic medication" and "no clinically significant nausea" or "only mild nausea" in the delayed phase (24-120 hours post-chemotherapy). Secondary endpoints were the proportion of patients with a complete response (CR: "no vomiting" and "no rescue an...Continue Reading

References

Oct 1, 1992·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·C M LindleyJ T Osterhaus
Nov 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L RichardsonA Levine
Jul 25, 2003·Cancer·Charles G MartinDavid Osoba
Feb 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P EisenbergA Macciocchi
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F RoilaUNKNOWN ESMO/MASCC Guidelines Working Group
Jun 25, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Luigi CelioUNKNOWN Italian Trials in Medical Oncology Group
Aug 21, 2010·The Journal of Pharmacology and Experimental Therapeutics·Camilo RojasBarbara S Slusher
Sep 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ethan BaschUNKNOWN American Society of Clinical Oncology
Jan 29, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ralph BocciaDaniel Voisin
Jun 15, 2013·American Journal of Clinical Oncology·Leslie S BradfordDon S Dizon
Mar 5, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Marko PopovicEdward Chow
Jul 22, 2014·Journal of Gynecologic Oncology·Dong Hoon SuhKyung-Hun Lee
Mar 11, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K JordanM Aapro
May 8, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Naoto FurukawaFuminori Ito
Sep 17, 2015·Current Treatment Options in Oncology·Joseph Menczer
Aug 12, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Fausto RoilaBernardo Rapoport
Feb 6, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Fuminori Ito, Naoto Furukawa
Jul 9, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Michael J BergerMiranda Hughes
Aug 2, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul J HeskethGary H Lyman
Jun 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K JordanM Aapro

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