Efficacy of paracetamol-esterified methionine versus cysteine or methionine on paracetamol-induced hepatic GSH depletion and plasma ALAT level in mice

Biochemical Pharmacology
L A SkoglundO Aalen

Abstract

The effect of paracetamol-N-acetyl-DL-methionate (PAM) in preventing paracetamol-induced hepatic glutathione (GSH) depletion and hepatic cell damage assessed by plasma ALAT level, was compared to those of concomitantly administered paracetamol and N-acetyl-L-cysteine (NAC) or N-acetyl-DL-methionine (NAM) and paracetamol 400 mg/kg (P) alone. PAM, NAM and NAC reduced hepatic GSH depletion compared to P. The concomitant administration of GSH precursors in either form apparently maintained hepatic cell integrity as evaluated by plasma ALAT compared to predose and 16 hr control measurements. No statistically significant difference between PAM, NAM and NAC was observed. In group P a statistically significant, but transitory, rise in plasma ALAT level following dosage was seen. NAC was more effective than PAM and NAM in the prevention of GSH depletion 1 hr after dosing but was less effective in promoting de novo GSH synthesis towards 16 hr. There was no statistically significant difference between PAM and NAM with respect to effect on GSH depletion or hepatic cell integrity. PAM and NAM increased the GSH level significantly above control level 16 hr after dosing. PAM is rapidly cleaved to paracetamol and methionine following dosage as...Continue Reading

References

Jan 1, 1977·The Journal of Nutrition·N TateishiH Shiozaki
Mar 15, 1977·European Journal of Biochemistry·J Högberg, A Kristoferson
Oct 1, 1979·Biochemical Pharmacology·J G Hart, J A Timbrell
Mar 1, 1975·The Journal of Nutrition·R W BoggsR A Damico
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·N KaplowitzM Ookhtens
Apr 20, 1974·Lancet·A E McLean
Mar 1, 1967·Medicine·R J Clermont, T C Chalmers
Oct 1, 1966·Biochemical Pharmacology·A L SheffnerH P Sarett
Jan 1, 1984·European Journal of Clinical Pharmacology·E J Ariëns
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·L F Prescott, J A Critchley
Jan 1, 1983·Annual Review of Biochemistry·A J Cooper
Oct 1, 1984·Biochemical Pharmacology·J O MinersD J Birkett
Jan 1, 1984·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·D V Parke, C Ioannides
Apr 1, 1983·The Journal of Clinical Investigation·B H LauterburgJ R Mitchell
Apr 1, 1983·Journal of Applied Toxicology : JAT·M C Savides, F W Oehme
Jan 1, 1980·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·D J Jollow
Jul 1, 1981·Toxicology and Applied Pharmacology·R M WalkerW J Racz
Jan 1, 1955·The Journal of Clinical Investigation·A KARMENJ S LADUE
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.