Efficacy of Paracetamol in Closure of Ductus Arteriosus in Infants under 32 Weeks of Gestation

Frontiers in Pediatrics
Ines TofeJuan Luis Perez-Navero

Abstract

Standard medical treatment for patent ductus arteriosus (PDA) closure has been indomethacin/ibuprofen or surgical ligation. Up to date, new strategies have been reported with paracetamol. The aim of this study was to present our experience with intravenous paracetamol for closing PDA in preterm neonates presenting contraindication to ibuprofen or ibuprofen had failed and no candidates for surgical ligation because of huge instability. We conducted a retrospective case series study in a neonatal intensive care unit from a tertiary hospital. 9 preterm infants ≤32 weeks of gestational age with hemodynamically significant PDA (hsPDA) were enrolled. They received 15 mg/kg/6h intravenous paracetamol for ductal closure. Demographic data and transaminase levels before and after treatment were collected. 30 preterm babies were diagnosed of hsPDA. 11/30 received ibuprofen with closure in 81.1%. 9 received intravenous paracetamol mainly due to bleeding disorders or thrombocytopenia. Successful closure on paracetamol was achieved in seven of nine babies (77.7%). There was a significant increase in transaminase levels in two patients. They required no treatment for normalization. Paracetamol is an effective option in closure PDA. It should ...Continue Reading

References

Feb 23, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·T del moralE Bancalari
May 23, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·Mehmet Yekta OncelUgur Dilmen
Apr 23, 2013·Archives of Disease in Childhood·Karel AllegaertBart van Overmeire
Sep 13, 2013·Journal of Clinical Neonatology·Rahul SinhaS S Dalal
Dec 19, 2013·Journal of Postgraduate Medicine·B JasaniR N Nanavati
Jan 28, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Irena KesselAvi Rotschild
Mar 19, 2014·Pediatrics·Dany E WeiszPrakesh S Shah
May 24, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·E NadirM Feldman
Mar 18, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Asli MemisogluEren Ozek
Apr 8, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·D E WeiszP J McNamara
May 6, 2016·European Journal of Pediatrics·Enrico ValerioPaola Lago
Oct 8, 2016·Iranian Journal of Pediatrics·Mohammad Mehdi BagheriHamid Mossavi
Aug 23, 2017·BioMed Research International·Flaminia BardanzelluVassilios Fanos

❮ Previous
Next ❯

Citations

Feb 23, 2021·The Journal of Pediatrics·Clyde J Wright

❮ Previous
Next ❯

Methods Mentioned

BETA
cesarean section

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The Journal of Thoracic and Cardiovascular Surgery
Alessandro Giardini, Graham Derrick
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Asli MemisogluEren Ozek
© 2022 Meta ULC. All rights reserved