Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: a comparison with methotrexate

Toxicon : Official Journal of the International Society on Toxinology
Simone Cristina YamasakiPaulo Flavio Silveira

Abstract

The use of bee venom (BV) to treat inflammation and pain in arthritis has become increasingly common. This study aimed to compare the effects of BV and methotrexate (MTX), the most used disease-modifying anti-rheumatic drug, in arthritic rats. Edema, erythema, cyanosis, hyperalgesia, reduction of the body mass gain, high circulating tumor necrosis factor alpha (TNF-α) and anti-type II collagen antibodies (AACII), and altered activity of basic (APB) and neutral (APN) aminopeptidases and dipeptidyl peptidase IV (DPPIV) are present in arthritic rats. MTX and/or BV do not affect AACII in healthy or arthritic individuals, but restores TNF-α to normal levels in arthritic rats. BV restores body mass gain to normal levels and MTX ameliorates body mass gain. BV contains DPPIV. BV restores APN in synovial fluid (SF) and in soluble fraction (S) from synovial tissue (ST), and DPPIV in solubilized membrane-bound fraction (M) from peripheral blood mononuclear cells (PBMCs). MTX restores APN of SF, as well as ameliorates APB of S-PBMCs, APN of S-ST and DPPIV of M-PBMCs. The combination therapy does not overcome the effects of BV or MTX alone on the peptidase activities. Edema is ameliorated by MTX or BV alone. MTX, but not BV, is effective in...Continue Reading

References

Jun 18, 2002·The American Journal of Chinese Medicine·Seong Soo KangSeok Hwa Choi
Jan 10, 2003·Clinical and Experimental Immunology·Y N WilliamsT Kubota
Jan 7, 2004·Peptides·Elaine Gasparello-ClementePaulo Flávio Silveira
Mar 30, 2004·European Journal of Immunology·Max Albert HietalaMarcela Pekna
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Akira Hattori, Masafumi Tsujimoto
Apr 21, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Jae-Dong LeeSabina Lim
Jun 14, 2005·Journal of Clinical Pharmacology·Tanya Doan, Elena Massarotti
Aug 23, 2005·Biochimica Et Biophysica Acta·Nico PeirenFrans J Jacobs
Sep 26, 2006·Immunopharmacology and Immunotoxicology·A MirshafieyS Cuzzocrea
Oct 4, 2007·Annals of the New York Academy of Sciences·Dirk ReinholdStefan Brocke
Jul 2, 2008·Journal of Endocrinological Investigation·L Zambotti-VillelaP F Silveira
Oct 16, 2008·Current Drug Targets·V ThanawalaR Ghosh
Mar 31, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Siegfried AnsorgeMichael Täger
May 15, 2009·Arthritis Research & Therapy·Ronenn Roubenoff
Jun 6, 2009·BMC Musculoskeletal Disorders·Anita HartogJohan Garssen
Jun 10, 2009·Cell and Tissue Research·Kutty Selva Nandakumar
Nov 6, 2009·Current Pain and Headache Reports·Patrick B Wood
Nov 26, 2009·Autoimmunity Reviews·Ljudmila Stojanovich
Apr 7, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lucie SromovaAleksi Sedo
May 12, 2010·Journal of Ethnopharmacology·Izabella Cordeiro Freire Saad RachedSuzana Beatriz Veríssimo de Mello
Jul 21, 2010·European Journal of Pharmacology·Ahmed M Al-AbdAshraf B Abdel-Naim
Sep 4, 2010·Science·Robert J SnelgroveJ Edwin Blalock
Feb 18, 2011·Regulatory Peptides·Mariana Trivilin MendesPaulo Flavio Silveira
May 21, 2011·The Breast : Official Journal of the European Society of Mastology·José Manuel Martínez-MartosMaría Jesús Ramírez-Expósito
Oct 11, 2011·Regulatory Peptides·Simone Cristina YamasakiPaulo Flavio Silveira
Jul 4, 2012·Molecular Immunology·Monika Pavkova GoldbergovaPetr Nemec
Dec 19, 2012·Rheumatology·Katherine S Upchurch, Jonathan Kay
Jan 8, 2013·Cancer Chemotherapy and Pharmacology·Samira Sadat AbolmaaliRassoul Dinarvand
Apr 5, 2014·BioMed Research International·Mariana Trivilin Mendes, Paulo Flavio Silveira

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Citations

Oct 1, 2020·Toxins·Ting-Yen Lin, Ching-Liang Hsieh
Jun 18, 2020·International Journal of Nanomedicine·Yun-Chun ZhaoCai-Hong Zheng

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