Efficacy of partially hydrolyzed guar gum (PHGG) supplemented modified oral rehydration solution in the treatment of severely malnourished children with watery diarrhoea: a randomised double-blind controlled trial

Journal of Health, Population, and Nutrition
N H AlamR Meier

Abstract

To examine whether PHGG added ORS reduce duration of diarrhoea, stool output and enhance weight gain. In a double-blind controlled clinical trial, 126 malnourished children (weight for length/weight for age < -3 Z-score with or without pedal edema), aged 6 - 36 months with acute diarrhoea <7 days were studied in two treatment groups; 63 received modified WHO ORS (Na 75, K 40, Cl 87, citrate 7, glucose 90 mmol/L) with PHGG 15 g/L (study group); 63 received modified WHO ORS without PHGG (control). Other treatments were similar in both groups. The study protocol was approved by Ethics Committee of icddr,b; the study was carried out at the Dhaka Hospital. The mean duration of diarrhoea (h) was significantly shorter in children of the study group (Study vs. control, mean ± SD, 57 ± 31 vs. 75 ± 39, p = 0.01). Although there was a trend in stool weight reduction in children receiving ORS with PHGG (study vs. control, stool weight (g), mean ± SD; 1(st) 24 hour, 854.03 ± 532.15 vs. 949.11 ± 544.33, p = 0.32; 2(nd) 24 hour, 579.84 ± 466.01 vs. 761.26 ± 631.64, p = 0.069; 3(rd) 24 hour, 385.87 ± 454.09 vs. 495.73 ± 487.61, p = 0.196), especially in 2(nd) 24 h period, the difference was not statistically significant. The mean time (day) to...Continue Reading

References

Apr 1, 1986·Scandinavian Journal of Gastroenterology·T Høverstad
Jan 1, 1982·The British Journal of Surgery·W E Roediger, D A Rae
Feb 3, 2000·The New England Journal of Medicine·B S RamakrishnaH J Binder
Jan 6, 2001·Journal of Pediatric Gastroenterology and Nutrition·N H AlamN Gyr
Mar 1, 2003·Paediatric Drugs·Nure H Alam, Hasan Ashraf
Jun 5, 2003·Nutrition·Joanne L Slavin, Norman A Greenberg
Apr 28, 2006·Journal of Pediatric Gastroenterology and Nutrition·P RaghupathyHenry J Binder
Sep 26, 2006·International Journal of Epidemiology·Charles P LarsonNikhil Roy

❮ Previous
Next ❯

Citations

Nov 2, 2017·Wellcome Open Research·Kirsty A HoustonKathryn Maitland
Feb 1, 2020·Journal of Clinical Biochemistry and Nutrition·Hiroya IidaMasaji Tani
Oct 3, 2019·International Journal of Molecular Sciences·Xiaoyan LiuZhengqiang Jiang
Dec 21, 2017·Expert Opinion on Investigational Drugs·Hania SzajewskaJan Łukasik
Feb 2, 2021·Expert Review of Gastroenterology & Hepatology·Claudio RomanoValeria Dipasquale

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
X-ray
urine collector

Software Mentioned

statistical package for Social Science ( SPSS PC
icddr

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.