Efficacy of peripheral morphine analgesia in inflamed, non-inflamed and perineural tissue of dental surgery patients

Journal of Pain and Symptom Management
R LikarM Schäfer

Abstract

In a clinical model of dental pain, the analgesic efficacy of local morphine treatment was examined under three different conditions. Patients undergoing dental surgery were randomly assigned to an injection of local anesthetic (articaine) plus 1 mg morphine either into inflamed (n = 14; trial 1) or non-inflamed (n = 24; trial 2) submucous tissue or perineurally n = 19; trial 3). Patients in the control group for each condition (n = 13, trial 1; n = 26, trial 2; n = 16, trial 3) received articaine plus saline. Postoperative pain intensity was assessed by the visual analog scale (VAS) and numeric rating scale (NRS) at 0, 2, 4, 6, 8, 10, 12, 16, 20, and 24 h. In addition, patients recorded the occurrence of side effects and the supplemental consumption of diclofenac. Immediately after the operation, pain scores were reduced to a similar extent in all groups, most likely due to the local anesthetic effect. Thereafter, pain scores and supplemental consumption of diclofenac were significantly lower in patients receiving 1 mg morphine into inflamed submucous tissue than in the control group for up to 24 h. Patients receiving 1 mg morphine into non-inflamed tissue or perineurally did not show any further reduction in pain scores compa...Continue Reading

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Citations

Sep 1, 2005·Der Schmerz·J Oeltjenbruns, M Schäfer
Dec 31, 2004·Current Pain and Headache Reports·Jochen Oeltjenbruns, Michael Schäfer
Jan 17, 2014·Journal of Maxillofacial and Oral Surgery·S Praveen KumarS M Kotrashetti
Jan 12, 2008·European Journal of Anaesthesiology·O CanbayU Aypar
Apr 10, 2008·British Journal of Anaesthesia·H L RittnerC Stein
Oct 6, 2006·Current Opinion in Anaesthesiology·Diane L DeHaven-Hudkins
Aug 2, 2008·Clinical and Experimental Pharmacology & Physiology·Jalal ZaringhalamVahideh Mirzaiee
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Apr 2, 2008·Neuroscience Letters·H L RittnerC Stein
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Aug 30, 2005·Journal of Pain and Symptom Management·Anne Cecile Gairard-DoryElisabeth Quoix
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May 22, 2020·Oral Diseases·Qing LiuFang Huang
Jun 25, 2005·Journal of Wound Care·C VernassiereJ L Schmutz
May 22, 2021·Frontiers in Neuroscience·Qing LiuFang Huang

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