Efficacy of Pharmacotherapy for Smoking Cessation in Adolescent Smokers: A Meta-analysis of Randomized Controlled Trials

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Seung-Kwon Myung, Joo-Young Park

Abstract

This study aimed to evaluate the efficacy of pharmacotherapy for smoking cessation among adolescent smokers by using a meta-analysis of randomized controlled trials (RCTs). PubMed, EMBASE, and Cochrane Library were searched from the inception to January 20, 2018. We included RCTs of pharmacotherapy for smoking cessation among adolescent smokers aged less than 20 years. Data were pooled using a random-effects meta-analysis. The primary outcome measures were a smoking abstinence rate and its relative risk (RR) at the longest follow-up period in each study validated by biochemical markers. Among a total of 1035 articles searched, nine RCTs, which involved 1188 adolescent smokers aged 12-20 years with 627 in the intervention group and 561 in the control group, were included in the final analysis. In the random-effects meta-analysis of all the nine trials, pharmacotherapy showed a increased abstinence rate (RR = 1.62; 95% confidence interval [CI] = 1.08 to 2.44, I2 = 0.0%), compared with the control group. Subgroup meta-analyses by follow-up period showed an increased abstinence rate at 4 weeks (RR = 1.87; 95% CI = 1.22 to 2.87; n = 4) and a nonsignificantly increased abstinence rate during the longer term follow-up periods at 8, 12...Continue Reading

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Citations

Mar 19, 2019·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Nicholas ChadiSion K Harris
Aug 24, 2019·Journal of Molecular Neuroscience : MN·Feng-Ling XuBao-Jie Wang
Oct 16, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Erin A McClureKevin M Gray
Sep 16, 2019·Current Psychiatry Reports·Matthew C FadusKevin M Gray
Sep 24, 2019·JAMA Pediatrics·Nicholas ChadiScott E Hadland
Apr 23, 2019·Journal of Child and Adolescent Psychopharmacology·Lindsay M SquegliaKevin M Gray
Dec 24, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Zachary W AdamsLeslie A Hulvershorn
Jun 2, 2021·CPT: Pharmacometrics & Systems Pharmacology·Daryl J FediukWonkyung Byon
Aug 2, 2021·Drug and Alcohol Dependence·Aukje E J MertensMirte A G Kuipers

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