Efficacy of photodynamic therapy versus antibiotics as an adjunct to scaling and root planing in the treatment of periodontitis: A systematic review and meta-analysis

Photodiagnosis and Photodynamic Therapy
Zohaib AkramAyesha Hanif

Abstract

To determine whether treatment with antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) yield better clinical periodontal outcomes than antibiotics (AB) as adjunct to SRP in periodontitis. Electronic searches were conducted in databases (MEDLINE, PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases) up to and including April 2017. Five randomized trials were included. All studies used the combined approach aPDT+SRP and AB+SRP in the test and control group respectively. The follow up period ranged from 12 to 48 weeks. All studies used diode lasers. The wavelengths, power density and duration of irradiation used were 670 nanometre, 75 milliwatts per square centimeters and 60s respectively. None of the studies showed additional benefits of aPDT at follow up. Considering the effects of adjunctive aPDT as compared to AB, a high degree of heterogeneity for periodontal probing depth (PPD) (p<0.0001, I2=87.47%) was noticed among both the groups. Meta-analysis showed significant clinical attachment level (CAL) gain (WMD=0.60, 95% CI=0.25 to 0.95, p=0.001), and not PPD reduction (WMD=0.67, 95% CI=-0.36 to 1.71, p=0.204) for aP...Continue Reading

References

Jan 20, 1996·British Dental Journal·M RadvarD F Kinane
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Aug 28, 2004·Periodontology 2000·Isao Ishikawa, Pierre Baehni
Dec 29, 2004·Diabetes Research and Clinical Practice·Nessar Ahmed
May 10, 2005·Journal of Photochemistry and Photobiology. B, Biology·Peter Meisel, Thomas Kocher
Nov 22, 2005·Lancet·Bruce L PihlstromNewell W Johnson
Jul 27, 2007·Journal of Dental Research·K Konopka, T Goslinski
Oct 2, 2009·Journal of Periodontology·Mohammad S Al-ZahraniMossad M Al-Sherbini
Mar 30, 2010·Journal of Clinical Epidemiology·David MoherUNKNOWN Consolidated Standards of Reporting Trials Group
Jun 2, 2015·New Microbes and New Infections·I RocaJ Vila
Jul 18, 2015·Photodiagnosis and Photodynamic Therapy·Fahim VohraFawad Javed
Sep 4, 2015·Journal of Oral Rehabilitation·M AltamashP-E Engström
Aug 25, 2016·Journal of Clinical Periodontology·Dagmar F BunaesKnut N Leknes
Aug 29, 2016·Archives of Oral Biology·Zohaib AkramSyarida Hasnur Safii

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Citations

Mar 28, 2018·Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry ... [et Al.]·Zohaib AkramFawad Javed
Oct 26, 2018·Journal of Investigative and Clinical Dentistry·Nouf Al-Shibani
Oct 8, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Israel Alexandre de Araújo SenaAna Rafaela Luz de Aquino Martins
Aug 18, 2020·Journal of Lasers in Medical Sciences·Nahid DerikvandSeyedeh Sara Ghasemi
Aug 28, 2019·Photodiagnosis and Photodynamic Therapy·Mohammed AlrabiahFahim Vohra
Feb 26, 2021·Photodiagnosis and Photodynamic Therapy·Muhammad Abdullah KamranIbrahim Alshahrani
Jul 24, 2021·Clinical Case Reports·Soher Nagi JayashMudar Kamal
Nov 16, 2020·International Journal of Pharmaceutics·Amanda Letícia Polli SilvestreMarlus Chorilli

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