Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease

The Journal of Dermatology
Toshio HasegawaShigaku Ikeda

Abstract

Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is reported to be an effective and safe treatment for superficial non-melanoma skin cancers. We have developed an photodynamic therapy with topical delta-aminolevulinic acid (ALA-PDT) protocol using intense pulsed light (IPL) for treating Bowen's disease (BD). Three patients diagnosed with BD by skin biopsy were recruited in this study. They received IPL treatment after 3 h of occlusive dressing with application of ALA. This protocol was repeated every 2 weeks for a total of five sessions. The treated areas did not show any signs of BD for more than 1 year; therefore, it appeared that the affected areas showed improvement in all the patients. No patients withdrew from the study because of side-effects. ALA-PDT with IPL as a light source is well tolerated by patients and is beneficial for treating BD.

References

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Citations

Oct 15, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kate RossNeil Fenske
Mar 19, 2014·Journal of Cutaneous Medicine and Surgery·Heidi Wat, Marlene Dytoc
Feb 6, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Heidi WatMitchel P Goldman
Feb 3, 2011·Archives of Dermatological Research·M A CalinM Tautan
Sep 22, 2011·The Journal of Dermatology·Toshio HasegawaShigaku Ikeda
Mar 7, 2021·International Journal of Molecular Sciences·Aleksandra KaczorowskaKatarzyna Borowska

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