Efficacy of polyanionic collagen matrices for bone defect healing

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Lenaldo B RochaMarcos A Rossi

Abstract

Polyanionic collagen-elastin matrices (PCEMs) possess attractive properties, such as extra negative charges, piezoelectricity, and extra RGD sites, which could make them effective in the treatment of bone defects. Although they are biocompatible with the osteogenesis process, it is unknown if PCEMs could aid in the recovery of bone defects in challenging situations. To evaluate this hypothesis, three PCEMs, differing in their negative charge density, were implanted in rat calvarial defects. Specimens harvested at 3, 7, 15, 30, and 60 days after implantation were evaluated radiographically and histologically. Two matrices were able to sustain the osteogenesis process and quickly recover the lost bone structure. The third, and most electronegative, left matrix remnants amidst the areas of new bone. The control showed bone formation limited to the boundaries of the defect. These results suggest that some PCEMs might become a useful resource in the treatment of bone defects.

References

Jan 1, 1995·Journal of Periodontology·K KubotaM E Wikesjö
Apr 1, 1996·Journal of Biomedical Materials Research·Y IkadaE Fukada
Apr 11, 2000·Journal of Biomedical Materials Research·C DuK de Groot
Aug 28, 2001·Journal of Biomedical Materials Research·M OhgakiK Yamashita
Jan 5, 2002·Biomaterials·Lenaldo B RochaMarcos A Rossi
Nov 7, 2002·Biomaterials·Fabiana Paim RosaElcio Marcantonio
Dec 25, 2002·The Journal of Oral Implantology·Maria G PatinoRobert E Cohen

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Citations

Jun 21, 2013·Journal of Materials Science. Materials in Medicine·Fúlvio Borges MiguelFabiana Paim Rosa
Sep 19, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Patrícia da Luz MoreiraArnaldo Rodrigues Santos
Jul 4, 2006·Journal of Biomedical Materials Research. Part a·Lenaldo B RochaMarcos A Rossi

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