Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice

Neoplasia : an International Journal for Oncology Research
Ying YanMing You

Abstract

The objective of this investigation was to determine the efficacy of several novel agents in preventing lung tumorigenesis in mice. We evaluated polyphenon E, red ginseng, and rapamycin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene for their ability to inhibit pulmonary adenoma formation and growth. We found that treatment with polyphenon E exhibited a significant reduction on both tumor multiplicity and tumor load (tumor multiplicity x tumor volume) in a dose-dependent fashion. Polyphenon E (2% wt/wt) in the diet reduced tumor multiplicity by 46% and tumor load by 94%. This result provided key evidence in support of a phase II clinical chemoprevention trial of lung cancer. Administration of red ginseng in drinking water decreased tumor multiplicity by 36% and tumor load by 70%. The mammalian target of rapamycin inhibitor rapamycin showed significant efficacy against lung tumor growth in the tumor progression protocol and reduced tumor load by 84%. The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice.

References

Dec 1, 1990·International Journal of Epidemiology·T K Yun, S Y Choi
Aug 22, 1985·The New England Journal of Medicine·J E Fielding
Feb 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J CaoJ E Klaunig
Mar 1, 1997·Carcinogenesis·H WitschiK E Pinkerton
Nov 14, 1997·Science·W K Hong, M B Sporn
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·P E BurnettD M Sabatini
Apr 9, 1998·Journal of Ethnopharmacology·C XiaoguangH Rui
Aug 11, 1998·International Journal of Epidemiology·T K Yun, S Y Choi
Jan 15, 1999·Hematology/oncology Clinics of North America·M You, G Bergman
Dec 2, 1999·Experimental Cell Research·A Dufner, G Thomas
Mar 10, 2001·BioFactors·C S YangM J Lee
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·S GuptaH Mukhtar
Dec 19, 2001·Journal of Korean Medical Science·T K Yun
Dec 19, 2001·Journal of Korean Medical Science·M J Wargovich
Mar 22, 2002·The Lancet Oncology·T K Yun
Nov 9, 2002·European Journal of Biochemistry·Christopher G Proud
Dec 13, 1952·British Medical Journal·R DOLL, A B HILL
Mar 19, 2004·Nature·Hans-Guido WendelScott W Lowe
May 4, 2004·Nature Reviews. Cancer·Mary-Ann Bjornsti, Peter J Houghton
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Isabelle Sansal, William R Sellers
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janice P Dutcher
Dec 8, 2004·Current Cancer Drug Targets·Ravi D RaoJann N Sarkaria

❮ Previous
Next ❯

Citations

Jan 30, 2010·Pharmaceutical Research·Qi ZhangMing You
Jun 25, 2009·Nature Reviews. Cancer·Stephen S HechtDorothy K Hatsukami
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shumei SongRobert S Bresalier
Dec 24, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Regan M Memmott, Phillip A Dennis
May 28, 2009·Cancer Prevention Research·Ann M Bode, Zigang Dong
Oct 5, 2012·Cancer Prevention Research·Stephen D HurstingNathan A Berger
Apr 3, 2007·Tobacco Control·Aiyin ChenElisa Tong
Jul 9, 2009·Cancer Prevention Research·Yian WangMing You
Jul 8, 2011·Cancer Prevention Research·L Allyson CheckleyJohn DiGiovanni
Sep 24, 2015·Oncology Reports·Jagan M R PatlollaChinthalapally V Rao
Dec 17, 2008·Clinical Lung Cancer·Sumanta Kumar PalKaren L Reckamp
Jul 29, 2011·Annals of the New York Academy of Sciences·Tricia MooreJohn DiGiovanni
Aug 27, 2010·Environmental and Molecular Mutagenesis·Barbara L ParsonsPage B McKinzie
Aug 7, 2009·Environmental and Molecular Mutagenesis·Fanxue MengBarbara L Parsons
Jul 19, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ying FuFung-Lung Chung
Jan 13, 2018·Biological Procedures Online·Lijing JiaoLing Xu
Apr 26, 2012·Integrative Cancer Therapies·Heidi FritzDean Fergusson
Sep 1, 2015·Oncotarget·Jianyi LuJimin Gao
Sep 3, 2010·Cancer Prevention Research·Jeffrey A Engelman, Lewis C Cantley
Apr 4, 2013·Cancer Prevention Research·Jing PanMing You
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Courtney A GranvillePhillip A Dennis
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gang LuChung S Yang
May 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haishan HuangChuanshu Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.