PMID: 2119950Oct 1, 1990Paper

Efficacy of positive vs negative pressure ventilation in unloading the respiratory muscles

Chest
M J BelmanR Shadmehr

Abstract

We compared the efficacy of positive pressure ventilation (PPV) vs negative pressure ventilation (NPV) in providing ventilatory muscle rest for five normal subjects and six patients with chronic obstructive pulmonary disease (COPD). All participants underwent measurement of transdiaphragmatic pressure (Pdi), pressure time integral of the diaphragm (PTI), integrated diaphragmatic electromyogram (iEMG), minute ventilation (Ve), tidal volume (Vt), and end-tidal CO2 (etCO2) during 15 minutes of PPV and NPV. For each subject, ventilator adjustments were made to obtain Ve similar to levels measured during quiet breathing (QB). We found that the iEMG, Pdi, PTI, and average coefficient of variation of the tidal volume (CV-Vt) were consistently lower during PPV as compared with NPV (p = 0.01). The iEMG normalized for Ve and Vt was also significantly lower during PPV (p = 0.01). During PPV, subjects were mildly hyperventilated (lower etCO2 and higher Ve) compared with QB and NPV, but no significant correlation was noted between the change in etCO2 and the change in iEMG. The change in PTI was significantly correlated with the change in iEMG (p less than 0.01). We conclude that in the short term, PPV is more effective than NPV in reducing...Continue Reading

References

Jul 1, 1988·The American Review of Respiratory Disease·K G HenkeJ A Dempsey
Oct 1, 1988·Journal of Applied Physiology·D O RodensteinC Veriter
Jun 1, 1988·Journal of Applied Physiology·D O RodensteinD C Stănescu
Jul 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S FieldA Grassino
Jan 1, 1954·The Journal of Physiology·B BIGLAND, O C LIPPOLD

❮ Previous
Next ❯

Citations

Jun 28, 2000·Journal of Pain and Symptom Management·J P JanssensV Titelion
May 18, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G O'Brien, G J Criner
Mar 28, 2007·Archivos de bronconeumología·Jorge Y NemeF Javier Hurtado
Apr 1, 1996·Critical Care Medicine·N Abou-Shala, U Meduri
Mar 6, 1998·Archives of Disease in Childhood·A Thomson
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·S Mehta, N S Hill
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M GoriniD Tozzi
Apr 1, 1993·The American Review of Respiratory Disease·N S Hill
Feb 1, 1995·Chest·J F Masa JiménezF Fuentes Otero
Jan 23, 2008·Respiratory Research·Claudio TerzanoAngelo Petroianni
Nov 30, 2010·Respiratory Medicine·Georg-Christian FunkSylvia Hartl
Apr 12, 2017·Current Neurology and Neuroscience Reports·Antonella LoMauroAndrea Aliverti
May 15, 2007·American Journal of Respiratory and Critical Care Medicine·Gerard J CrinerUNKNOWN National Emphysema Treatment Trial Research Group
Aug 5, 2004·Critical Care Nursing Quarterly·Denise Fenstermacher, Dennis Hong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.