Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study.

BMC Cancer
Ryohei YukimotoHidetoshi Eguchi

Abstract

The presence of lateral pelvic lymph node (LLN) metastasis is an essential prognostic factor in rectal cancer patients. Thus, preoperative diagnosis of LLN metastasis is clinically important to determine the therapeutic strategy. The aim of this study was to evaluate the efficacy of preoperative positron emission tomography/computed tomography (PET/CT) in the diagnosis of LLN metastasis. Eighty-four patients with rectal cancer who underwent LLN dissection at Osaka University were included in this study. The maximum standardized uptake value (SUVmax) of the primary tumor and LLN were preoperatively calculated using PET/CT. Simultaneously, the short axis of the lymph node was measured using multi-detector row computed tomography (MDCT). The presence of metastases was evaluated by postoperative pathological examination. Of the 84 patients, LLN metastases developed in the left, right, and both LLN regions in 6, 7, and 2 patients, respectively. The diagnosis of the metastases was predicted with a sensitivity of 82%, specificity of 93%, positive predictive value of 58%, negative predictive value of 98%, false positive value of 7%, and false negative value of 18% when the cutoff value of the LLN SUVmax was set at 1.5. The cutoff value...Continue Reading

References

Feb 18, 2006·Annals of Surgical Oncology·Susan L GearhartRichard Wahl
Oct 17, 2006·Diseases of the Colon and Rectum·Kenichi SugiharaTetsuichiro Muto
Apr 22, 2008·Japanese Journal of Clinical Oncology·Yoshiyuki TsunodaNorio Saito
Jul 21, 2009·Annals of Surgical Oncology·Takayuki AkasuNoriyuki Moriyama
Sep 22, 2009·The Lancet Oncology·Panagiotis GeorgiouParis Tekkis
Nov 8, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OguraUNKNOWN Lateral Node Study Consortium
Oct 16, 2019·International Journal of Clinical Oncology·Akira WatanabeKen Shirabe

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