Efficacy of pre-supplementary motor area transcranial direct current stimulation for treatment resistant obsessive compulsive disorder: A randomized, double blinded, sham controlled trial

Brain Stimulation
Shayanth M GowdaY C Janardhan Reddy

Abstract

A significant proportion of obsessive compulsive disorder (OCD) patients do not respond to specific serotonin reuptake inhibitors (SSRIs). There is a need to evaluate novel treatment options for OCD. In this double blinded, randomized, sham controlled study, we investigated the efficacy of add-on transcranial direct current stimulation (tDCS) in reducing the symptoms in SSRI-resistant OCD patients by employing anodal pre-supplementary motor area (pre-SMA) stimulation. Twenty-five patients with DSM-IV OCD having persistent symptoms despite adequate and stable treatment with at least one SSRI were randomly allocated to receive 20 min of verum (active) 2-mA tDCS or sham stimulation twice daily on 5 consecutive days [anode over Pre-SMA; cathode over right supra-orbital area]. Response to treatment was defined as at least 35% reduction in the Yale-Brown Obsessive-Compulsive Scale (YBOCS) total score along with a Clinical Global Impression - Improvement (CGI-I) score of 1 (very much improved) or 2 (much improved). The response rate was significantly greater in the verum tDCS(4 out of 12) compared to sham-tDCS (0 out of 13) [Fisher's exact test, p = 0.04]. Repeated measures analysis of variance with tDCS type (verum vs. sham) as betwe...Continue Reading

Citations

Jan 17, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Renata de Melo Felipe da SilvaRoseli Gedanke Shavitt
Jul 23, 2020·Journal of Affective Disorders·Camila CosmoEduardo Pondé de Sena
Jan 23, 2021·Neuroscience and Biobehavioral Reviews·Stephanie HomanPhilipp Homan
Jan 9, 2021·Molecular Psychiatry·Elizabeth ShephardEuripedes C Miguel
Jul 28, 2020·The International Journal of Neuropsychopharmacology·Felipe FregniUNKNOWN Neuromodulation Center Working Group
May 1, 2021·Asian Journal of Psychiatry·Abel ThambyJanardhanan C Narayanaswamy

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