Abstract
Transcatheter arterial embolization (TAE) has been widely performed for renal angiomyolipomas (AMLs) as prophylaxis or emergency treatment. On the other hand, mammalian target of rapamycin (mTOR) inhibitors have recently been used for tuberous sclerosis (TSC)-related AMLs, and no comparison between the effectiveness of mTOR inhibitors versus prophylactic selective TAE has yet been performed. Therefore, the purpose of this study was to evaluate the efficacy of TAE for AML tumor volume reduction and predictors of tumor volume decrease over 50%, with reference to the EXIST-2 trial. A total of 44 patients who underwent 48 prophylactic embolization procedures for 50 AMLs in a single institution between 2004 and 2018 were included. Indications for TAE of AMLs were tumor size ≥4 cm or aneurysm ≥5 mm in diameter on contrast-enhanced computed tomography (CECT). Microspheres, ethanol, and micro-coils were used as embolic agents. The percentage volume reduction from before TAE to the minimum volume during follow-up after TAE was calculated, and predictors for 50% volume reduction were identified by univariate and multivariate binary logistic regression analyses. The technical success rate was 100% (50 of 50). No severe acute complications...Continue Reading
References
Jan 1, 1995·European Urology·Y FujiiY Takehara
Jul 1, 1994·Journal of Vascular and Interventional Radiology : JVIR·M C SoulenC Cope
Dec 1, 1994·The Journal of Urology·M J KennellyK J Cho
Jul 1, 1994·The Journal of Urology·J G van BaalS Verhoef
Dec 1, 1993·The Journal of Urology·M S SteinerF F Marshall
Oct 2, 2002·Radiology·Koichiro YamakadoKan Takeda
Dec 11, 2003·The Journal of Urology·Toru HarabayashiTomohiko Koyanagi
Jul 28, 2011·The Journal of Urology·Jacqueline D VillaltaMarshall L Stoller
Jan 15, 2013·Lancet·John J BisslerKlemens Budde
Sep 24, 2013·Pediatric Neurology·Hope NorthrupUNKNOWN International Tuberous Sclerosis Complex Consensus Group
Jul 15, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John J BisslerKlemens Budde
Nov 28, 2015·The Journal of Urology·Andrew S FlumRobert B Nadler
Aug 2, 2017·Journal of Vascular and Interventional Radiology : JVIR·Omid KhalilzadehBoris Nikolic
Aug 14, 2018·International Urology and Nephrology·Letao LinYinghua Zou