Abstract
Anticoagulation therapy with warfarin requires periodic monitoring of prothrombin time-international normalized ratio (PT-INR) and adequate dose adjustments based on the data to minimize the risk of bleeding and thromboembolic events. In our hospital, we have developed protocol-based pharmaceutical care, which we called protocol-based pharmacotherapy management (PBPM), for warfarin therapy. The protocol requires pharmacists to manage timing of blood sampling for measuring PT-INR and warfarin dosage determination based on an algorithm. This study evaluated the efficacy of PBPM in warfarin therapy by comparing to conventional pharmaceutical care. From October 2013 to June 2015, a total of 134 hospitalized patients who underwent cardiovascular surgeries received post-operative warfarin therapy. The early series of patients received warfarin therapy as the conventional care (control group, n=77), whereas the latter received warfarin therapy based on the PBPM (PBPM group, n=68). These patients formed the cohort of the present study and were retrospectively analysed. The indications for warfarin included aortic valve replacement (n=56), mitral valve replacement (n=4), mitral valve plasty (n=22) and atrial fibrillation (n=29). There w...Continue Reading
References
Jun 1, 1991·Australian and New Zealand Journal of Medicine·C J DoeckeA S Gallus
Jan 19, 1999·Archives of Internal Medicine·M A CrowtherJ Hirsh
May 30, 2003·The Annals of Pharmacotherapy·Gregory W RobertsVaughn S Eaton
Dec 4, 2003·JAMA : the Journal of the American Medical Association·Alan S GoDaniel E Singer
Jun 30, 2005·Journal of Clinical Pharmacy and Therapeutics·S L JacksonJ H Vial
Aug 1, 2006·Journal of the American College of Cardiology·Robert O BonowBarbara Riegel
Dec 13, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Joseph ThomasYogesh Punekar
Feb 9, 2007·Journal of Clinical Pharmacy and Therapeutics·I O PoonU K Braun
May 15, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·William E Dager, Michael P Gulseth
Jul 31, 2007·Journal of the American College of Cardiology·Albert Yuh-Jer ShenWansu Chen
Oct 2, 2007·Journal of Thrombosis and Thrombolysis·Scott Kaatz
Jul 24, 2008·Chest·Jack AnsellGualtiero Palareti
Jun 30, 2009·Pharmacotherapy·Robert MacLaren, C A Bond
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Yi WanYongyong Xu
Aug 19, 2011·BMC Family Practice·Stephanie YoungPatrick O'Shea
Oct 4, 2011·Journal of Thrombosis and Thrombolysis·Carol MotyckaKelly Jones
Aug 28, 2012·European Heart Journal·UNKNOWN Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC)Marian Zembala
Jun 1, 2013·General Thoracic and Cardiovascular Surgery·Hiroshi Furukawa, Kazuo Tanemoto
Jun 15, 2013·The International Journal of Pharmacy Practice·Richard S BourneBen J Dorward
Mar 14, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenji MinakataRyuzo Sakata
Apr 22, 2015·General Thoracic and Cardiovascular Surgery·Taro NakatsuRyuzo Sakata
Sep 9, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenji MinakataRyuzo Sakata
Citations
Nov 22, 2018·European Journal of Clinical Pharmacology·Yoshiki KatadaKazuo Matsubara
Dec 13, 2019·International Journal of Clinical Practice·Hirotsugu YamadaAkio Suzuki
Jun 11, 2020·Journal of Clinical Pharmacy and Therapeutics·Hiroaki IkesueTohru Hashida
Oct 10, 2018·Frontiers in Pharmacology·Leiliane Rodrigues MarcattoPaulo Caleb Junior Lima Santos
Feb 2, 2021·Journal of Pharmaceutical Health Care and Sciences·Yoshiki KatadaKazuo Matsubara
Aug 3, 2021·Journal of Pharmaceutical Health Care and Sciences·Eiji ShiwakuYuka Kobayashi