Efficacy of protocol-based pharmacotherapy management on anticoagulation with warfarin for patients with cardiovascular surgery

Journal of Clinical Pharmacy and Therapeutics
Y KatadaK Matsubara

Abstract

Anticoagulation therapy with warfarin requires periodic monitoring of prothrombin time-international normalized ratio (PT-INR) and adequate dose adjustments based on the data to minimize the risk of bleeding and thromboembolic events. In our hospital, we have developed protocol-based pharmaceutical care, which we called protocol-based pharmacotherapy management (PBPM), for warfarin therapy. The protocol requires pharmacists to manage timing of blood sampling for measuring PT-INR and warfarin dosage determination based on an algorithm. This study evaluated the efficacy of PBPM in warfarin therapy by comparing to conventional pharmaceutical care. From October 2013 to June 2015, a total of 134 hospitalized patients who underwent cardiovascular surgeries received post-operative warfarin therapy. The early series of patients received warfarin therapy as the conventional care (control group, n=77), whereas the latter received warfarin therapy based on the PBPM (PBPM group, n=68). These patients formed the cohort of the present study and were retrospectively analysed. The indications for warfarin included aortic valve replacement (n=56), mitral valve replacement (n=4), mitral valve plasty (n=22) and atrial fibrillation (n=29). There w...Continue Reading

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Citations

Nov 22, 2018·European Journal of Clinical Pharmacology·Yoshiki KatadaKazuo Matsubara
Oct 10, 2018·Frontiers in Pharmacology·Leiliane Rodrigues MarcattoPaulo Caleb Junior Lima Santos
Aug 3, 2021·Journal of Pharmaceutical Health Care and Sciences·Eiji ShiwakuYuka Kobayashi

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