Efficacy of proton pump inhibitor therapy for eosinophilic oesophagitis in 630 patients: results from the EoE connect registry

Alimentary Pharmacology & Therapeutics
Emilio J Laserna-MendietaEUREOS EoE CONNECT research group

Abstract

Proton pump inhibitors (PPIs) are the most commonly used first-line therapy for patients with eosinophilic oesophagitis (EoE). However, many aspects related to PPIs in EoE are still unknown. To assess the effectiveness of PPI therapy for EoE in real-world practice. This cross-sectional study collected data on PPI efficacy from the multicentre EoE CONNECT database. Clinical remission was defined as a decrease ≥50% in dysphagia symptom score; histological remission was defined as a peak eosinophil count below 15 eosinophils per high-power field. Factors associated with effectiveness of PPI therapy were identified by binary logistic regression multivariate analyses. Overall, 630 patients (76 children) received PPI as initial therapy (n = 600) or after failure to respond to other therapies (n = 30). PPI therapy achieved eosinophil density below 15 eosinophils per high-power field in 48.8% and a decreased symptom score ≥50% from baseline in 71.0% of patients. More EoE patients with an inflammatory rather than stricturing phenotype accomplished clinico-histological remission after PPI therapy (OR 3.7; 95% CI, 1.4-9.5); as well as those who prolonged treatment length from 8 to 12 weeks (OR 2.7; 95% CI, 1.3-5.3). After achieving clinic...Continue Reading

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Jun 8, 2021·Seminars in Immunopathology·Luc BiedermannPhilipp Schreiner
Jun 3, 2021·Nutrients·Pierfrancesco VisaggiNicola de Bortoli
Jun 23, 2021·Zeitschrift für Gastroenterologie·Stephan MiehlkeAhmed Madisch
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Oct 6, 2021·JAMA : the Journal of the American Medical Association·Amanda Muir, Gary W Falk

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