Efficacy of PTX3 in a rat model of invasive aspergillosis.

Antimicrobial Agents and Chemotherapy
Pietro Lo GiudiceGiovanni Salvatori

Abstract

Pentraxin 3 (PTX3) is an acute-phase glycoprotein with a nonredundant function in the host resistance to Aspergillus fumigatus. PTX3 activity was evaluated against pulmonary aspergillosis in rats immunosuppressed with cortisone acetate. PTX3 enhanced the survival rate and reduced the lung fungal burden of infected rats in both therapeutic and prophylactic modalities. Thus, we extended the protective activity of PTX3 in pulmonary aspergillosis to corticosteroid-induced immunodeficiency, which is a relevant clinical condition in graft-versus-host disease and in solid organ transplant.

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Citations

Jul 3, 2013·Immunobiology·Amal Atia Mhfuod El-MuzghiMilena Kataranovski
Sep 26, 2012·Antimicrobial Agents and Chemotherapy·Pietro Lo GiudiceGiovanni Salvatori
Dec 14, 2011·Immunotherapy·Charalampos AntachopoulosEmmanuel Roilides
Oct 16, 2014·Critical Care : the Official Journal of the Critical Care Forum·Tommaso MauriAntonio Pesenti
Oct 21, 2015·Trends in Microbiology·Suan-Sin FooSuresh Mahalingam
Dec 13, 2012·Annals of the New York Academy of Sciences·Mark S GresnigtFrank L van de Veerdonk
Jun 12, 2013·Seminars in Immunology·Antonio InforzatoAlberto Mantovani
Jul 30, 2014·Antimicrobial Agents and Chemotherapy·Emanuele MarraGiovanni Salvatori
Jan 30, 2020·FEBS Letters·Raffaella ParenteAntonio Inforzato
Jun 1, 2017·Frontiers in Microbiology·Guillaume Desoubeaux, Carolyn Cray
Dec 12, 2018·PLoS Pathogens·Valeria CiancarellaMaria Lina Bernardini
Jan 29, 2019·Frontiers in Microbiology·Sabina Herrera, Shahid Husain
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Qian HeXin Su
Aug 10, 2018·Frontiers in Microbiology·Qi Hui SamLouis Yi Ann Chai
Oct 14, 2020·Antimicrobial Agents and Chemotherapy·María Velasco-de AndrésFrancisco Lozano
Apr 27, 2021·Veterinary Immunology and Immunopathology·Michelle Townsend, Baljit Singh

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