Efficacy of recombinant human adenovirus-p53 combined with chemotherapy for locally advanced cervical cancer: A clinical trial

Oncology Letters
Jie XiaoFumin Liu

Abstract

The aim of this study was to evaluate the efficacy and safety of recombinant human adenovirus-p53 (rhAd-p53) combined with neoadjuvant chemotherapy in treatment of locally advanced cervical cancer (LACC). A total of 40 patients with LACC (stage IB2 to IIIA) were randomized into 2 groups (n=20 each): PVB group (cisplatin + vincristine + bleomycin, intravenously) and combined group (rhAd-p53 gene therapy + neoadjuvant chemotherapy). Both groups underwent a course of chemotherapy; the only exception was the injection of the rhAd-p53 solution 1×10(12) VP intratumorally at an interval of three days thrice in the combined group thereafter. The tumor sizes and adverse events in both groups were observed. The expression of vascular endothelial growth factor (VEGF), protein p53 and micro-vessel density (MVD) in tumor tissue was respectively determined by immunohistochemistry. The evaluation was performed three weeks after the completion of chemotherapy. The efficacy was 75% in the PVB group versus 95% efficacy in the combined group; the tumor size was reduced by 11.42±2.78 cm(2) in PVB group versus the significant shrinkage of 15.25±4.00 cm(2) in the combined group (P<0.05). The expression of VEGF, p53 and MVD was downregulated in both ...Continue Reading

References

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Citations

May 28, 2020·Cancers·Ángela ÁyenHouria Boulaiz
Nov 12, 2020·BMJ Evidence-based Medicine·Eric A ApaydinSusanne Hempel
Dec 5, 2020·Critical Reviews in Oncology/hematology·Xiangxuan ZhaoZaiming Lu

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