PMID: 8589000Nov 1, 1995Paper

Efficacy of recombinant human granulocyte colony-stimulating factor and recombinant human granulocyte-macrophage colony-stimulating factor in neutropenic children with malignancies

Pediatric Hematology and Oncology
E LydakiM Kalmanti

Abstract

The difference between the effects of administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was studied in 39 children with neutropenia secondary to chemotherapy (absolute neutrophil count (ANC) less than 1,500/microliters. The children were divided into two groups. The first group (G-CSF) included 25 children (12 with acute lymphoblastic leukemia [ALL]-non-Hodgkin's lymphoma [NHL] and 13 with solid tumors) and the second group (GM-CSF) included 14 children (5 with ALL-NHL and 9 with solid tumors). All 39 children received of either G-CSF or GM-CSF (5 micrograms/kg/day) subcutaneously at the end of each chemotherapy course for a maximum duration of 14 days. The effect of G-CSF and GM-CSF on the ANC, the antibiotic therapy administration, and the length of hospital stay were studied for both groups at two cycles of chemotherapy. During both cycles a faster rise of ANC was observed in the children of the first group (G-CSF) compared with those of the second group (GM-CSF), but there was no difference in either the incidence of antibiotic therapy administration between the two groups (26% vs 25%) or the length of hospita...Continue Reading

References

Jan 2, 1992·International Journal of Cancer. Journal International Du Cancer·B I LordT M Dexter
Sep 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A NeidhartF B Oldham
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B I LordT M Dexter
Aug 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V T DeVita
Mar 1, 1994·Pediatric Hematology and Oncology·Y L Danon
Mar 1, 1994·Pediatric Hematology and Oncology·T FerenczJ D Borsi

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Citations

Feb 14, 2002·British Journal of Haematology·Thomas Lehrnbecher, Karl Welte
Apr 20, 2001·Paediatric Drugs·L M Wagner, W L Furman
Mar 29, 2000·Allergy·F Levi-Schaffer
Sep 1, 1996·Pediatric Hematology and Oncology·M Kalmanti
Aug 26, 2000·Scandinavian Journal of Infectious Diseases·A WarrisT G Abrahamsen
Apr 1, 2009·Expert Review of Hematology·Thomas Lehrnbecher, Ursula Creutzig
Apr 29, 1999·Medical and Pediatric Oncology·G WehlF M Fink
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Julia BohliusAndreas Engert

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