Efficacy of recombinant human interleukin 7 in a patient with severe lymphopenia-related progressive multifocal leukoencephalopathy

Open Forum Infectious Diseases
Jacques GasnaultYassine Taoufik

Abstract

In this study, we report the case of a patient with profound lymphopenia after allogenic bone marrow transplantation who developed severe progressive multifocal leukoencephalopathy. Single-agent recombinant human interleukin-7 therapy was associated with restoration of anti-John Cunningham polyomavirus (JCV) T-cell responses, JCV clearance from cerebrospinal fluid, and a dramatic clinical improvement.

References

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Citations

Jan 15, 2016·Neurology. Neuroimmunology and Neuroinflammation·Catharina C GrossLuisa Klotz
May 5, 2016·Neurology. Neuroimmunology and Neuroinflammation·Dhanashri P MiskinIgor J Koralnik
May 24, 2016·La Presse médicale·Laurence HellouinHervé Levesque
Jul 17, 2016·Journal of Neurovirology·David N Soleimani-MeigooniRobert C Bucelli
Oct 1, 2016·Current Infectious Disease Reports·Deanna Saylor, Arun Venkatesan
Nov 26, 2015·Therapeutic Advances in Neurological Disorders·Dejan PavlovicUNKNOWN Progressive Multifocal Leukeoncephalopathy Consortium
Mar 8, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Cai YuanShahram Mori
Jun 16, 2017·Journal of Hematology & Oncology·Aurélie TormoMoutih Rafei
Dec 16, 2018·Journal of Clinical Immunology·Jérôme HadjadjFelipe Suarez
Mar 14, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·S Richard DunhamDavid B Clifford
Nov 22, 2020·Nature Reviews. Neurology·Irene CorteseAvindra Nath

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Methods Mentioned

BETA
lavage
flow cytometry

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