Efficacy of Reconstituted Oral Chloral Hydrate from Crystals for Echocardiography Sedation

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Garick D HillPeter C Frommelt

Abstract

Chloral hydrate has been the drug of choice for uncooperative infants and children requiring sedation for echocardiography. Recently, the commercially available liquid formulation was discontinued by the manufacturer, and the only oral form of chloral hydrate available was made using reconstituted crystals. The aim of this study was to compare sedation efficacy before and after this change in chloral hydrate formulas. Consecutive patients presenting for echocardiography sedation during the transition from the manufacturer-derived old formulation to the locally reconstituted new formulation were retrospectively reviewed for time to onset of level 3 sedation, duration of level ≤3 sedation, requirement for additional sedative medications, sedation failure, ability to complete the echocardiographic examination, and adverse events related to the sedatives. The cohort included 124 patients (63 old, 61 new). Although the mean age at sedation was younger for the new group, the weight and average dose of chloral hydrate used were not significantly different. There were no adverse events in either group. Time to onset of sedation was the same between the two formulations, but the duration of sedation was significantly shorter for the new...Continue Reading

References

Nov 1, 1990·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J G StevensonK Zamberlin
Jun 22, 1974·British Medical Journal·M A RamsayR Goodwin
Aug 1, 1996·The Journal of Pediatrics·K L NapoliG R Martin
Nov 3, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Charles N WardenThomas R Kimball
Feb 4, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Susan C NicolsonDavid R Jobes
Jun 16, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kenan W D SternOscar J Benavidez

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Citations

Feb 26, 2019·Echocardiography·Madhusudan GanigaraRajesh Shenoy
Jul 12, 2019·Paediatric Drugs·Eytan KaplanElhanan Nahum
Jul 24, 2021·Cardiology in the Young·David E SaudekPeter C Frommelt
Dec 18, 2018·ACS Omega·Alessandra S KiametisWerner Treptow

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