Efficacy of rifaximin vaginal tablets in treatment of bacterial vaginosis: a molecular characterization of the vaginal microbiota.

Antimicrobial Agents and Chemotherapy
Federica CrucianiBeatrice Vitali

Abstract

Bacterial vaginosis (BV) is a common vaginal disorder characterized by an alteration of the vaginal bacterial morphotypes, associated with sexually transmitted infections and adverse pregnancy outcomes. The purpose of the present study was to evaluate the impact of different doses of rifaximin vaginal tablets (100 mg/day for 5 days, 25 mg/day for 5 days, and 100 mg/day for 2 days) on the vaginal microbiota of 102 European patients with BV enrolled in a multicenter, double-blind, randomized, placebo-controlled study. An integrated molecular approach based on quantitative PCR (qPCR) and PCR-denaturing gradient gel electrophoresis (PCR-DGGE) was used to investigate the effects of vaginal tablets containing the antibiotic. An increase in members of the genus Lactobacillus and a decrease in the BV-related bacterial groups after the antibiotic treatment were demonstrated by qPCR. PCR-DGGE profiles confirmed the capability of rifaximin to modulate the composition of the vaginal microbial communities and to reduce their complexity. This molecular analysis supported the clinical observation that rifaximin at 25 mg/day for 5 days represents an effective treatment to be used in future pivotal studies for the treatment of BV.

References

May 1, 1979·The Journal of Clinical Investigation·K C ChenK K Holmes
Jul 1, 1991·Analytical Biochemistry·B J BassamP M Gresshoff
Oct 1, 1991·American Journal of Obstetrics and Gynecology·P A Mårdh
Oct 1, 1987·European Journal of Clinical Microbiology·E HolstP A Mårdh
Jan 1, 1983·British Journal of Hospital Medicine·S G Dawson, J R Harris
Feb 1, 1993·Diagnostic Microbiology and Infectious Disease·W W HooverR N Jones
Jan 1, 1996·International Journal of Systematic Bacteriology·A TiveljungH J Monstein
Apr 25, 2000·Annual Review of Medicine·J D Sobel
Dec 20, 2000·American Journal of Obstetrics and Gynecology·J R Schwebke
Feb 15, 2001·Expert Opinion on Investigational Drugs·A Bryskier
Sep 25, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jody VoorspoelsMarleen Temmerman
Nov 22, 2002·FEMS Immunology and Medical Microbiology·M Reza ZariffardGregory T Spear
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Harold C WiesenfeldRichard L Sweet
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas L CherpesSharon L Hillier
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·A LiebetrauL Dubreuil
Dec 3, 2004·Applied and Environmental Microbiology·Takahiro MatsukiRyuichiro Tanaka
Apr 28, 2005·Chemotherapy·Carmelo Scarpignato, Iva Pelosini
Nov 2, 2005·Obstetrics and Gynecology·Alexander SwidsinskiHerbert Lochs
Nov 4, 2005·The New England Journal of Medicine·David N FredricksJeanne M Marrazzo
Jun 6, 2006·Acta Obstetricia Et Gynecologica Scandinavica·Per Daniel Johannes RönnqvistEva Elisabeth Grahn-Håkansson
Sep 13, 2006·FEMS Immunology and Medical Microbiology·Jasadee KaewsrichanJaturavit Kongprasertkit
Jan 5, 2007·Journal of Clinical Microbiology·Michael J FerrisDavid H Martin
Mar 9, 2007·Journal of Perinatal Medicine·Christopher PretoriusRonald F Lamont
May 20, 2008·Applied and Environmental Microbiology·Brian B OakleyDavid N Fredricks
Sep 3, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E BiagiP Brigidi
Jan 23, 2009·Journal of Clinical Microbiology·Tae Kyung KimBrenda A Wilson
Jun 23, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·G G DondersS Van Lierde
Mar 23, 2010·Journal of Clinical Microbiology·Marcela Zozaya-HinchliffeMichael J Ferris
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacques RavelLarry J Forney
Jan 22, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·R F LamontR Romero
Feb 22, 2011·Journal of Applied Microbiology·Y TurovskiyM L Chikindas
Jun 15, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·Ggg DondersD Rezeberga
Jul 12, 2011·Clinical Therapeutics·Anastasia Rivkin, Suzanna Gim
Mar 1, 2012·Journal of Lower Genital Tract Disease·Camila MarconiGilbert G G Donders

❮ Previous
Next ❯

Citations

Mar 4, 2014·Expert Opinion on Pharmacotherapy·Gilbert G G DondersDace Rezeberga
Mar 28, 2013·Expert Opinion on Medical Diagnostics·Charlene W J Africa
Sep 2, 2015·Diabetes & Metabolism·P Njomnang SohB Bouhanick
Sep 20, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B VitaliL Laghi
Jun 27, 2013·The Journal of Antimicrobial Chemotherapy·Federica CrucianiBeatrice Vitali
Dec 30, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kai-tao HuZhong-ming Zeng
Apr 9, 2014·Antimicrobial Agents and Chemotherapy·Luca LaghiBeatrice Vitali
Dec 10, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G DondersJ Byamughisa
Jan 1, 2014·Journal of Pharmaceutics·Onkar SinghAmit K Goyal
Mar 23, 2021·Expert Opinion on Pharmacotherapy·Jack D Sobel, Ryan Sobel
May 16, 2017·Research in Microbiology·Gilbert G G DondersPedro Vieira-Baptista

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Bacterial Vaginosis

Bacterial vaginosis can increase the risk of sexually transmitted infections and in rare cases lead to pelvic inflammatory diseases. Discover the latest research on Bacterial Vaginosis here.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Hans BalinkJoris Grond
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Filip JankuRazelle Kurzrock
© 2021 Meta ULC. All rights reserved