Efficacy of Scalp Cooling in Preventing Chemotherapy-Induced Alopecia in Breast Cancer Patients Receiving Adjuvant Docetaxel and Cyclophosphamide Chemotherapy

Clinical Breast Cancer
Tessa CiglerAnne Moore

Abstract

Chemotherapy-induced alopecia (CIA) is a distressing adverse effect of many chemotherapy agents. The TC (docetaxel [Taxotere] and cyclophosphamide) chemotherapy regimen is typically associated with complete alopecia. Scalp cooling with cold caps has been reported to minimize or prevent CIA. We conducted a prospective study to assess efficacy of scalp cooling in preventing CIA among women receiving adjuvant TC chemotherapy for breast cancer. Women at the Weill Cornell Breast Center who independently elected to use scalp cooling with cold caps during adjuvant TC chemotherapy were asked to participate. Degree of hair loss was assessed by a single practitioner using Dean's alopecia scale (grade 1/excellent [< 25% hair loss], grade 2/good [25%-50% hair loss], grade 3/moderate [50%-75% hair loss], grade 4/poor [> 75% hair loss]), by digital photographs, and by patient self-report of hair thinning or the need to wear a wig/head covering, or both. Assessments were made before each chemotherapy treatment and at follow-up visits between 3 weeks and 3 months after completion of chemotherapy. Of 20 evaluable patients, 10% reported a need to wear a wig/head covering at the follow-up visit. Dean's alopecia score was excellent for 65% of pati...Continue Reading

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Citations

Oct 5, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·V V ShahJ J Jimenez
May 28, 2016·British Journal of Nursing : BJN·Annie Young, Azra Arif
Nov 21, 2018·Reviews on Recent Clinical Trials·Tiziana ProchiloAlberto Zaniboni
Sep 13, 2019·EMBO Molecular Medicine·Talveen S PurbaRalf Paus
Sep 28, 2017·The Oncologist·Christopher John DunnillNikolaos Theodoros Georgopoulos
Jun 28, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jung-Woo ChaeAlexandre Chan
Sep 19, 2017·Breast Cancer Research and Treatment·Brooke A RiceMichelle E Melisko
Jan 9, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·WeiLian CongChunLan Zhou
Jul 20, 2020·The Journal of Investigative Dermatology·Iain S HaslamZhiCao Yue
Apr 14, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shurui WangFangyuan Zhang

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