Efficacy of screening women at high risk of hereditary ovarian cancer: results of an 11-year cohort study

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Katja N GaarenstroomG G Kenter

Abstract

The outcome of screening and prophylactic surgery in 269 women at high risk of hereditary ovarian cancer is reported. Screening was performed using transvaginal ultrasound and serum CA125 testing. Mean follow-up was 26 months (583 person-years). A total of 113 (42%) of 269 women had a pathogenic BRCA1 or BRCA2 mutation, and 127 (47%) of 269 women underwent salpingo-oophorectomy. No occult cancers were found. In eight women having both elevated CA125 levels and abnormal ultrasound findings, a malignancy was found. Four of these cancers (one borderline, one stage Ia, one stage IIIb, and one stage IIIc ovarian or peritoneal cancer) were detected at the first screening visit. One stage IIIb and one stage IIIc cancer were detected at the second screening visit after 12 months, and two interval stage IIIc and IV cancers were detected 8 and 10 months after the first screening visit. No peritoneal carcinoma was found among those 114 women who underwent bilateral salpingo-oophorectomy with normal or benign pathology results, after a mean follow-up of 16 months (152 person-years). We conclude that the efficacy of screening women at high risk of ovarian cancer seems poor because the majority of cancers were detected at an advanced stage.

References

Aug 1, 1995·Gynecologic Oncology·W T Creasman
May 15, 1997·The New England Journal of Medicine·J P StruewingM A Tucker
Dec 16, 1998·British Journal of Obstetrics and Gynaecology·R BellT Sheldon
Feb 19, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H F VasenM Caligo
May 23, 2001·Ultrasound in Medicine & Biology·K J Taylor, P E Schwartz
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lauren ScheuerKenneth Offit
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas S FrankGregory C Critchfield
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander LiedeSteven A Narod
May 25, 2002·The New England Journal of Medicine·Noah D KauffKenneth Offit
May 25, 2002·The New England Journal of Medicine·Timothy R RebbeckUNKNOWN Prevention and Observation of Surgical End Points Study Group
Oct 24, 2002·The American Journal of Nursing·Lenore L Harris
Nov 5, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·Usha Menon, Ian Jacobs
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
Dec 12, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Bruce A WernessM Steven Piver
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Russell Hogg, Michael Friedlander

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Citations

Jan 15, 2013·Current Treatment Options in Oncology·Susan MiesfeldtChristine Duarte
Mar 28, 2008·Current Oncology Reports·Anthony P Gulati, Susan M Domchek
Feb 27, 2010·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Kaylene J ReadyKaren H Lu
Apr 16, 2009·European Journal of Human Genetics : EJHG·D Gareth R EvansFiona Lalloo
Jul 10, 2009·The New England Journal of Medicine·Daniel L Clarke-Pearson
Oct 30, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GadducciR Tana
Dec 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam N RosenthalIan J Jacobs
Aug 18, 2009·Biomarkers in Medicine·Dimitra SasaroliNathalie Scholler
Oct 2, 2013·Familial Cancer·Bettina MeiserKelly-Anne Phillips
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Jonathan G BijronPaul J van Diest
May 30, 2012·Obstetrics and Gynecology Clinics of North America·Lori L Ballinger
Dec 7, 2007·Obstetrics and Gynecology Clinics of North America·James C PavelkaBeth Y Karlan
Dec 7, 2007·Obstetrics and Gynecology Clinics of North America·Rebecca Byler DannKristin K Zorn
Jul 16, 2015·Gynecologic Oncology·Gerasimos TzortzatosMiriam Mints
Jan 16, 2007·Current Opinion in Obstetrics & Gynecology·Susan M Domchek, Timothy R Rebbeck
Nov 28, 2008·International Journal of Cancer. Journal International Du Cancer·Nienke M van der VeldeGeertruida H de Bock
Nov 19, 2010·Ultrasound Quarterly·Douglas L BrownCarolyn M Zelop
Nov 21, 2013·Menopause : the Journal of the North American Menopause Society·Claudia MarchettiPerluigi Bendetti Panici
Oct 27, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Alison H TrainerMichael Friedlander
Aug 5, 2008·Clinical Obstetrics and Gynecology·Nanette Santoro
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lovise MaehlePål Møller
Apr 23, 2009·Molecular Oncology·Henry T LynchAndrew K Godwin

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