Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-analysis.

Gastroenterology
Christopher J BlackAlexander C Ford

Abstract

Several secretagogues have been approved for the treatment of irritable bowel syndrome with constipation (IBS-C). However, their relative efficacy is unclear because there have been no head-to-head randomized controlled trials. We conducted a network meta-analysis to compare their efficacies in patients with IBS-C. We searched MEDLINE, EMBASE, EMBASE Classic, and the Cochrane Central Register of Controlled Trials through June 2018 to identify randomized controlled trials assessing the efficacy of secretagogues in adults with IBS-C. Trials included in the analysis reported a dichotomous assessment of overall response to therapy, and data were pooled using a random-effects model. Efficacy and safety of secretagogues were reported as a pooled relative risk with 95% confidence interval to summarize the effect of each comparison tested, and treatments were ranked according to their P score. We identified 15 eligible randomized controlled trials of secretagogues that included 8462 patients. Linaclotide, lubiprostone, plecanatide, and tenapanor were superior to placebo for the treatment of IBS-C. Linaclotide (290 μg once daily) was ranked first in efficacy based on the end point recommended by the Food and Drug Administration for tria...Continue Reading

Citations

Nov 5, 2019·JAMA : the Journal of the American Medical Association·Arnold Wald
Dec 13, 2019·BMJ : British Medical Journal·Leonardo H EusebiAlexander C Ford
Dec 14, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Anthony C JohnsonBeverley Greenwood-Van Meerveld
Jun 2, 2020·Expert Review of Clinical Pharmacology·Emanuele SinagraMarcello Maida
Dec 14, 2019·Digestive Diseases and Sciences·Adrijana D'SilvaMaitreyi Raman
Nov 8, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ayesha ShahGerald Holtmann
Aug 25, 2020·Current Opinion in Infectious Diseases·Sailaja PisipatiMark S Riddle
Sep 5, 2020·Alimentary Pharmacology & Therapeutics·Christopher J BlackAlexander C Ford
Aug 29, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael Camilleri
May 10, 2020·Expert Opinion on Drug Metabolism & Toxicology·Taraneh MousaviMohammad Abdollahi
May 19, 2020·Frontline Gastroenterology·James MauriceAnton V Emmanuel
Feb 5, 2021·Journal of Gastroenterology·Shin FukudoKazuhiko Koike
Oct 4, 2020·The American Journal of Gastroenterology·Brigida BarberioAlexander C Ford
Nov 13, 2020·The American Journal of Gastroenterology·Christopher J Black, Alexander C Ford
Oct 29, 2020·The American Journal of Gastroenterology·Christopher J BlackAlexander C Ford
Jan 23, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Abishek Arokiadoss, H Christian Weber
Mar 28, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Alexandra R OrtengrenEric D Shah
Oct 11, 2020·The American Journal of Gastroenterology·Eric D ShahWilliam D Chey
Jul 16, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Christopher J BlackAlexander C Ford
Jul 29, 2020·Gastroenterology Clinics of North America·Lauren Stemboroski, Ron Schey
Apr 22, 2021·The Lancet. Gastroenterology & Hepatology·Christopher J Black, Alexander C Ford
Apr 12, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brigida BarberioAlexander C Ford
May 14, 2021·The American Journal of Gastroenterology·Eric D ShahWilliam D Chey
Apr 15, 2020·Gastroenterology·Christopher J BlackAlexander C Ford
May 7, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vivek C GoodooryAlexander C Ford
Jun 7, 2021·The Lancet. Gastroenterology & Hepatology·Brigida BarberioAlexander C Ford
Apr 13, 2021·The American Journal of Gastroenterology·Vivek C GoodooryAlexander C Ford
May 28, 2020·Frontline Gastroenterology·Christopher J Black, Alexander Charles Ford
Jul 7, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurie KeeferAlexander C Ford
Aug 24, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brigida BarberioAlexander C Ford
Sep 18, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Vivek C GoodooryAlexander C Ford
Oct 31, 2021·Alimentary Pharmacology & Therapeutics·Neele DellschaftRobin Spiller

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