Efficacy of short-term growth hormone treatment in prepubertal children with idiopathic short stature

Yonsei Medical Journal
Ho-Seong KimDuk Hee Kim

Abstract

It has been reported that daily recombinant human growth hormone (GH) treatment showed beneficial effects on growth in prepubertal children with idiopathic short stature (ISS). The present study aimed to validate the GH (Eutropin®) effect on growth promotion and safety after short-term GH treatment. This study was an open-label, multicenter, interventional study conducted at nine university hospitals in Korea between 2008 and 2009. Thirty six prepubertal children with ISS were enrolled in this study to receive 6-month GH treatment. Yearly growth rate, height standard deviation score (SDS), and adverse events were investigated during treatment. After 26 weeks of GH treatment, the height velocity significantly increased by 6.36±3.36 cm/year (p<0.001). The lower end of one-sided 95% confidence interval was 5.22 cm/year, far greater than the predefined effect size. The gain in height SDS at week 26 was 0.57±0.27 (p<0.0001). Bone age significantly increased after GH treatment, however, bone maturation rate (bone age for chronological age) showed limited advancement. This 26-week GH treatment was effective in increasing serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 from baseline (p<0.0001). Eutr...Continue Reading

References

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Dec 21, 2010·The Journal of Pediatrics·Arlan L Rosenbloom

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Citations

Jul 17, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Sung-Hwan ChoiChung-Ju Hwang
May 9, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hwal Rim JeongJin Soon Hwang
Apr 4, 2018·Annals of Pediatric Endocrinology & Metabolism·Sochung ChungKee-Hyoung Lee
Jul 12, 2017·Annals of Pediatric Endocrinology & Metabolism·Minji ImHeon-Seok Han

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Methods Mentioned

BETA
ISS
X-ray
SGA

Software Mentioned

SPSS

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