Efficacy of Siddha formulation Kalpaamruthaa in ameliorating joint destruction in rheumatoid arthritis in rats

Chemico-biological Interactions
Rajendran MythilypriyaPanchanadam Sachdanandam

Abstract

Rheumatoid arthritis (RA) is a kind of chronic inflammatory autoimmune disease. The degradation of extracellular matrix and cartilage pave way in understanding the molecular mechanisms in RA. Degradation of cartilage is a more complex event involving the local release of metallaoproteases and lysosomal enzymes that mediate inflammation in joints and in the synovial fluid in RA. In the present study, the efficacy of a Siddha preparation named Kalpaamruthaa (KA) in ameliorating the disease process via markedly reducing the joint destruction was demonstrated in adjuvant induced arthritis rat model. KA consists of Semecarpus anacardium nut milk extract (SA), dried powder of Emblica officinalis fruit and honey. Both SA and KA were administered at dose of 150 mg/kg b.wt. for 14 days after 14 days of adjuvant injection in rats. The activity of lysosomal enzymes, the level of collagen, glycosaminoglycans (GAGs) and its degradative products were analyzed in control and experimental animals. The study revealed that KA exhibited a profound reduction (p<0.05) in the activities of lysosomal enzymes and thereby decreasing (p<0.05) the levels of GAGs and its fractions when compared to arthritis rats. The latter was confirmed by Safrannin O st...Continue Reading

References

Dec 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·D Maruhn
Sep 1, 1976·Agents and Actions·B ExerL Riesterer
Jan 1, 1991·Archives of Toxicology·D J FawthropD S Davies
May 1, 1988·The Journal of Urology·T I HwangC Y Pak
Jan 1, 1987·Annals of the New York Academy of Sciences·R I SchwarzN Owens
Jan 1, 1986·Annals of the Rheumatic Diseases·C J MorrisM M Steven
Jan 20, 1972·The New England Journal of Medicine·G Weissmann
Jan 19, 1973·Biochimica Et Biophysica Acta·G TettamantiV Zambotti
Jul 1, 1972·Annals of the Rheumatic Diseases·Z TrnavskáK Trnavský
Oct 14, 1970·Biochimica Et Biophysica Acta·E Delvin, R Gianetto
Apr 1, 1983·Biochemical Pharmacology·B Havsteen
Nov 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A M Agha, M Z Gad
Mar 14, 1998·Osteoarthritis and Cartilage·G A HomandbergJ M Williams
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·T M HaqqiH Mukhtar
May 1, 1999·Archives of Biochemistry and Biophysics·R AlbertiniP M Abuja
Sep 1, 1994·Osteoarthritis and Cartilage·P M van der KraanW B van den Berg
Nov 21, 2001·Arthritis Research·J S Mort, C J Billington
Jul 10, 2002·Biochemistry·Dong WangJindrich Kopecek
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR
Dec 10, 2003·British Journal of Pharmacology·Mirna Marques BezerraFrancisco Airton Castro da Rocha
Mar 8, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P NawratJ A Pałka
Mar 2, 2006·Biological & Pharmaceutical Bulletin·Krishnamurthy VeenaPanchanatham Sachdanandam

❮ Previous
Next ❯

Citations

Mar 27, 2012·Rheumatology International·Samuel Joshua PragasamMahaboobKhan Rasool
Mar 6, 2012·Inflammation·Vachana MurunikkaraMahaboobKhan Rasool
Oct 31, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S SaravananV Duraipandiyan
Jan 10, 2012·Asian Pacific Journal of Tropical Medicine·Alka MehtaG B Shah
Jul 25, 2021·Food & Function·Sahdeo PrasadSubash C Gupta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here