Feb 10, 2010

Efficacy of simvastatin or ezetimibe on tissue factor, von Willebrand's factor and C-reactive protein in patients with hypercholesterolaemia

Archives of Cardiovascular Diseases
Peggy KostakouDennis V Cokkinos


Statins have favourable effects on lipid profiles, decrease total mortality and have many pleiotropic effects. To determine and compare the pleiotropic effects of simvastatin and ezetimibe in dyslipidaemic patients. Forty-four patients (20 postmenopausal women) with low-density lipoprotein cholesterol >130 mg/dL (or >100mg/dL in patients with coronary artery disease or its equivalent) were treated with simvastatin 10mg daily (n = 21) or ezetimibe 10mg daily (n = 23). In blood samples taken before and three months after treatment, we measured the concentration of total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B, lipoprotein(a), homocysteine, tissue factor, von Willebrand's factor and C-reactive protein. Baseline lipid profiles and haematological variables were similar in both groups. Simvastatin and ezetimibe decreased the concentrations of total cholesterol (262 to 189 mg/dL, p < 0.001, and 268 to 220 mg/dL, p = 0.001, respectively), low-density lipoprotein cholesterol (177 to 114 mg/dL, p < 0.001 and 196 to 146 mg/dL, p < 0.001, respectively) and C-reactive protein (1.2 to 0.3 mg/dL, p = 0.001 and 2.8 to 0.8 mg/dL, p = 0.005, respect...Continue Reading

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Mentioned in this Paper

Biochemical Pathway
C-reactive Protein Measurement
Low Density Lipoprotein Cholesterol Measurement
Coronary Artery Disease
Anti-Inflammatory Agents
Apolipoproteins B
Total cholesterol
Serum Total Cholesterol Measurement

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