Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial.

BMC Infectious Diseases
Rubhana RaqibBirgitta Agerberth

Abstract

Treatment of shigellosis in rabbits with butyrate reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18) in the large intestinal epithelia. Here, we aimed to evaluate whether butyrate can be used as an adjunct to antibiotics in the treatment of shigellosis in patients. A randomized, double-blind, placebo-controlled, parallel-group designed clinical trial was conducted. Eighty adult patients with shigellosis were randomized to either the Intervention group (butyrate, n = 40) or the Placebo group (normal saline, n = 40). The Intervention group was given an enema containing sodium butyrate (80 mM), twice daily for 3 days, while the Placebo group received the same dose of normal saline. The primary endpoint of the trial was to assess the efficacy of butyrate in improving clinical, endoscopic and histological features of shigellosis. The secondary endpoint was to study the effect of butyrate on the induction of antimicrobial peptides in the rectum. Clinical outcomes were assessed and concentrations of antimicrobial peptides (LL-37, human beta defensin1 [HBD-1] and human beta defensin 3 [HBD-3]) and pro-inflammatory cytokines (interleukin-1β [IL-1β] and interleukin-8 [IL-8]) were measured in the stool. ...Continue Reading

Associated Clinical Trials

References

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Citations

Jul 17, 2012·European Journal of Nutrition·Yan CampbellAdrian F Gombart
May 21, 2013·World Journal of Gastroenterology : WJG·Jimmy Yip Chuen ChowChi Hin Cho
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Feb 15, 2019·Frontiers in Microbiology·Simona IacobLuminita Monica Luminos
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Jun 11, 2021·Frontiers in Physiology·Diliana Pérez-ReytorKatherine García
Jun 8, 2021·Infection and Immunity·Marina Gomes MachadoFrançois Trottein

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Methods Mentioned

BETA
biopsy
enzyme linked immunosorbent assay
biopsies

Clinical Trials Mentioned

NCT00800930

Software Mentioned

SPSS
SigmaStat
Systat

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