Efficacy of somatostatin and its analogues in prevention of postoperative complications after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials

Pancreas
Qiqiang ZengRong Jin

Abstract

The aim of this study was to evaluate the efficacy of somatostatin and its analogues in prevention of postoperative complications after pancreaticoduodenectomy. A literature search of the MEDLINE, EMBASE, and Cochrane databases was used to identify randomized controlled trials that compared somatostatin and its analogues with control group after pancreaticoduodenectomy. Meta-analytical techniques were applied to identify differences in outcomes between the 2 groups. A total of 8 studies were identified according to our inclusion criteria, including 2 studies using somatostatin, 5 studies using octreotide, and 1 study using vapreotide. The use of somatostatin or its analogues did not significantly benefit for reducing the incidence of pancreatic fistula (odds ratio [OR] 95% confidence interval [CI], 0.64-1.37; P = 0.73), total pancreas-specific postoperative complications (OR 95% CI, 0.63-1.42; P = 0.79), delayed gastric emptying (OR 95% CI, 0.50-1.78; P = 0.86), total complication (OR 95% CI, 0.73-1.70; P = 0.61), mortality (OR 95% CI, 0.59-7.72; P = 0.97), and length of postoperative hospital stay (weighted mean difference 95% CI, -7.74 to 4.47; P = 0.60). The use of somatostatin and its analogues does not significantly reduce...Continue Reading

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Sep 11, 1999·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·L RosenbergL Turcotte
Oct 31, 2001·The British Journal of Surgery·C GouillatB Gayet
Apr 3, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M FalconiP Pederzoli
Nov 23, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jordan M WinterCharles J Yeo
Dec 6, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B TopalF Penninckx

❮ Previous
Next ❯

Citations

May 8, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jens StandopJörg C Kalff
Jan 23, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Andreas Schmid FrymermanMohammed Reza Moussavian
Jun 3, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Keith D Lillemoe
Jun 30, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ulrich F WellnerTobias Keck
Aug 9, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Céline BrientEric Mirallié
Jan 6, 2009·Current Opinion in Gastroenterology·Oscar J Hines, Howard A Reber
Jan 1, 2010·Clinical and Experimental Gastroenterology·Anastasios KatsourakisAntonia Sioga
Apr 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Laureano Fernández-CruzJoana Ferrer
Feb 19, 2013·Clinics and Research in Hepatology and Gastroenterology·Emilie LermitePatrick Pessaux
Nov 19, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ulrich Friedrich WellnerTobias Keck
Oct 13, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Abigail E VallanceAndrew M Smith
Mar 3, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jamie R RobinsonAlexander A Parikh
Mar 21, 2012·The British Journal of Surgery·S L GansM A Boermeester
May 11, 2015·Cirugía española·Santiago Sánchez Cabús, Laureano Fernández-Cruz
May 12, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Haider MahdiMehdi Moselmi-Kebria
Aug 1, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z ChenY He
May 6, 2015·Indian Journal of Surgical Oncology·Prasanth PenumaduShailesh V Shrikhande
May 7, 2016·The Cochrane Database of Systematic Reviews·Zhiyong DongMaxim S Petrov
Sep 24, 2013·Orvosi hetilap·László HerszényiZsolt Tulassay
Aug 15, 2009·Magyar sebészet·Attila Oláh
Dec 10, 2009·Expert Opinion on Drug Safety·Jan BornscheinPeter Malfertheiner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.