Efficacy of South African Babesia bovis vaccine against field isolates

Ticks and Tick-borne Diseases
P C TroskieMichael P Combrink

Abstract

A high-passage Babesia bovis vaccine containing only one genotype population was, although protective, inferior compared to the immunity afforded by a lower passage of the same strain containing two populations. The 24 times serially passaged South African B. bovis S vaccine strain contain only a single parasite population (Bv80 allele A 558bp). Forty-four field isolates sampled were all found different with regard to the number and composition of the parasite populations present in each isolate. The extensive genotypic diversity in South Africa and the limited genotypic diversity observed in the S24 vaccine, raised the question on its ability to protect against such diverse populations. The 6 isolates selected for challenge in the current study originated from geographically distinct populations that also possessed thirteen unique genotypes based on the Bv80 gene and included strains that resulted in clinical disease. The strain coverage was therefore much greater than in previous studies on the protective ability of the S24 vaccine. Challenge of vaccinated cattle indicated that the vaccine gave adequate protection against 5/6 isolates. Protection against the remaining isolate proved inadequate. However, field observations in ...Continue Reading

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