Efficacy of Soy-Based Formulas in Alleviating Gastrointestinal Symptoms in Infants With Milk-Based Formula Intolerance: A Randomized Clinical Trial.

Clinical Pediatrics
John B Lasekan, G E Baggs

Abstract

A randomized, blinded pilot clinical study was conducted to assess gastrointestinal (GI) tolerance in healthy, full-term infants (2-9 weeks old), whose pediatricians recommended a formula change due to perceived cow's milk formula intolerance. Infants were randomized and exclusively fed either a commercial control soy formula (SF; n = 22), an experimental partially hydrolyzed SF (10% hydrolyzed, n = 23), or a 5% hydrolyzed SF (n = 26) for 2 weeks. Age-matched reference cohorts (n = 72) with no GI intolerance on milk-based formula were assessed in parallel. Results indicated that all SF-fed groups contributed to reduction (P < .05) in common GI tolerance symptoms to levels not different from the non-symptomatic reference cohort at study end. The control SF group had more reduced fussiness, gas, and crying and higher formed stools versus hydrolyzed SF groups. In conclusion, the study suggests that SFs reduced GI intolerance symptoms in otherwise healthy infants with poor tolerance on milk-based formulas.

References

Oct 1, 1988·The American Journal of Clinical Nutrition·N S Scrimshaw, E B Murray
Jun 1, 1985·The Journal of Pediatrics·B W ForsythJ M Leventhal
Oct 1, 1994·Current Opinion in Pediatrics·E H RingsH A Büller
Jun 1, 1994·Journal of the American College of Nutrition·H R ChurellaJ Jacobs
May 1, 1997·The American Journal of Clinical Nutrition·F L SuarezM D Levitt
Jul 13, 1999·Archives of Pediatrics & Adolescent Medicine·I M FayadM Santosham
Nov 2, 1999·Clinical Pediatrics·J B LasekanS Cho
Jan 5, 2000·Clinical Pediatrics·F P PolackM J Maisels
Feb 13, 2002·Journal of Pediatric Gastroenterology and Nutrition·Karin M OstromLarry K Pickering
Feb 13, 2002·Journal of Pediatric Gastroenterology and Nutrition·Christopher T CordleLarry K Pickering
Mar 22, 2002·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·D KanabarP Clayton
Dec 19, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Arne Høst
May 17, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G IaconoUNKNOWN Paediatric Study Group on Gastrointestinal Symptoms in Infancy
May 3, 2008·Pediatrics·Jatinder BhatiaUNKNOWN American Academy of Pediatrics Committee on Nutrition
Oct 4, 2008·Clinical Pediatrics·Carol Lynn BersethSusan Hazels Mitmesser
May 7, 2011·World Journal of Gastroenterology : WJG·Dámaso InfanteBernard Le Luyer
Mar 1, 2012·Pediatrics·UNKNOWN Section on Breastfeeding
Jan 16, 2014·Clinical Reviews in Allergy & Immunology·Yitzhak KatzPedro Alarcon
Jul 8, 2015·Clinical Pediatrics·Lauren M RossenKirsten A Herrick

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02456831

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.