Abstract
Renal impairment increases the risk of cardiovascular events and perioperative complications in patients with heart valve disease. This study aimed to determine the perioperative benefit of statin treatment related to baseline renal function in patients with rheumatic heart disease (RHD) who had cardiac surgery. We performed a retrospective study on 136 patients with RHD who underwent valve replacement surgery. The mean age of the patients was 56.2 years, 59.6% were female, 8.8% patients had diabetes mellitus, and 27.2% of patients had hypertension. Overall, 3 patients died, 2 underwent reoperation, and 25 underwent thoracentesis during the study period. For patients with renal impairment, there was a higher risk of thoracic puncture (odds ratio [OR]: 3.33; 95% confidence interval [CI]: 1.36, 8.11; P < 0.01) and a longer time of drainage (difference in means: 1; 95% CI: 0.88, 1.12; P < 0.01), intensive care unit (ICU) stay (difference in means: 0.2; 95% CI: 0.17, 0.23; P = 0.02), and hospital stay (difference in means: 6.6; 95% CI: 6.15, 7.05; P < 0.01) compared with normal renal function. Furthermore, statins were associated with a reduction in drainage time (difference in means: -1.50; 95% CI: -1.86, -1.14; P = 0.02), ICU sta...Continue Reading
References
Oct 1, 1989·The Annals of Thoracic Surgery·F AlajmoA Palminiello
Jun 18, 2003·Journal of Cardiac Surgery·Hakan GercekogluAzmi Ozler
Mar 3, 2007·Clinical Chemistry·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Jul 28, 2009·The Annals of Thoracic Surgery·Umberto BenedettoRiccardo Sinatra
Aug 12, 2009·Circulation·Eloi MarijonXavier Jouven
Nov 12, 2009·Interactive Cardiovascular and Thoracic Surgery·Engin UstaGerhard Ziemer
Nov 29, 2011·Nephrology·John R ProwleRinaldo Bellomo
Mar 1, 2012·Nature Reviews. Cardiology·Bo ReményiJonathan Carapetis
Oct 31, 2013·Annals of Surgery·Rey R AcedilloAmit X Garg
Mar 7, 2014·Toxins·Marion SalléeStéphane Burtey
Aug 27, 2014·Lancet·Paola ManducaSwee Ang
Apr 8, 2015·Circulation·Javaid IqbalPatrick W Serruys
Apr 25, 2015·Circulation·Michael H GewitzUNKNOWN American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular
Jul 29, 2015·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Nilam J SoniPaul H Mayo
Apr 14, 2016·Circulation·Arman Qamar, Deepak L Bhatt
Oct 14, 2016·Lancet·UNKNOWN GBD 2015 Mortality and Causes of Death Collaborators
Oct 19, 2016·Anesthesiology·David LegouisAlexandre Hertig
Dec 7, 2016·Critical Care : the Official Journal of the Critical Care Forum·Alessandro PutzuGiovanni Landoni
Feb 9, 2017·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Kerstin BenzKerstin Amann
Apr 1, 2017·Journal of Cardiothoracic Surgery·Yie Roei CheeDavid G Healy
Apr 5, 2017·Critical Care Medicine·Marc A BenoitSean van Diepen
Apr 30, 2017·Journal of Thoracic Disease·Shiguan LeZhinong Wang