PMID: 7519223Aug 1, 1994Paper

Efficacy of synthetic vaccines in the induction of cytotoxic T lymphocytes. Comparison of the costimulating support provided by helper T cells and lipoamino acid

Journal of Immunological Methods
E BorgesP Walden

Abstract

Synthetic vaccines that specifically induce active immunity mediated by cytotoxic T lymphocytes (CTL) are of great interest considering the central role of these cells in immune responses against intracellular antigens. The influence of specific T helper (Th) cell recruitment and of the potent immunostimulating lipoamino acid tripalmitoyl-S-glycerylcysteine (P3C) on CTL mediated immunity induced by CTL epitopes was analysed and compared. Synthetic peptides that represent CTL epitopes were found to be inefficient for CTL priming. However, when combined with peptides that contain Th cell epitopes, with proteins that carry multiple Th cell epitopes or with P3C, efficient priming of CTL was obtained. The costimulating support by P3C and proteins resulted in high cytolytic activities already after 9 days whereas, in the case of single helper epitopes, incubation periods of about 4 weeks were required. The effects of P3C and helper epitopes were additive.

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Citations

Jun 17, 1998·International Journal of Cancer. Journal International Du Cancer·M ReddishB M Longenecker
Jan 22, 2010·Amino Acids·Weiguang ZengDavid C Jackson
Jun 10, 1996·Journal of Immunological Methods·B R GundlachP Walden
Jan 29, 2002·International Journal for Parasitology·Alexander W PfaffWolfgang H Hoffmann
Dec 14, 2001·Molecular Immunology·O B EnglerA Cerny
Dec 14, 2001·Molecular Immunology·I P HunzikerA Cerny
Feb 1, 1996·Current Opinion in Immunology·P Walden
Apr 18, 2008·Nature Reviews. Cancer·Cornelis J M Melief, Sjoerd H van der Burg
Dec 5, 2002·Clinical and Experimental Dermatology·W Sterry, P Walden
May 10, 2000·Microbiology and Immunology·K KakugawaH Yamagishi
May 18, 2004·International Journal of Cancer. Journal International Du Cancer·Uwe TrefzerPeter Walden
Aug 3, 2007·Expert Review of Vaccines·Martijn S BijkerSjoerd H van der Burg
Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·U TrefzerP Walden
Dec 22, 2020·Journal of Medicinal Chemistry·Arshpreet KaurDeepak B Salunke
Oct 5, 2001·Journal of Medicinal Chemistry·A M PapiniM Vergelli

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