Efficacy of systematic lymphadenectomy and adjuvant radiotherapy in node-positive endometrial cancer patients

Gynecologic Oncology
Andrea MarianiKarl C Podratz

Abstract

To assess the efficacy of systematic lymphadenectomy and adjuvant radiotherapy in minimizing pelvic sidewall and para-aortic failures. Between January 1984 and December 2001, a total of 146 patients with stage III and IV endometrial cancer and lymph node metastases were treated at our institution. Adequate pelvic lymphadenectomy was defined as the removal of more than 10 pelvic lymph nodes, and adequate para-aortic lymphadenectomy was defined as removal of 5 or more para-aortic lymph nodes. The 24 patients who received adjuvant chemotherapy were excluded. We assessed the ability of adequate pelvic and para-aortic lymphadenectomy, together with radiotherapy, to prevent pelvic and para-aortic recurrences. Of the 122 patients studied, 94 (77%) had adequate pelvic lymphadenectomy and 47 (39%) had adequate para-aortic lymphadenectomy. Pelvic radiotherapy was administered to 78% and para-aortic radiotherapy to 29% of patients. Median follow-up of censored patients was 56 months. Twenty-five percent of patients had pelvic sidewall failure at 5 years. Pelvic sidewall failures at 5 years occurred in 57% of patients who had inadequate node dissection and/or no radiotherapy, compared with 10% for those having both adequate lymphadenectomy...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·B W CornG E Hanks
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·P G RoseR E Hunter
Apr 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J J PavyH Bartelink
Feb 22, 2002·Gynecologic Oncology·Andrea MarianiKarl C Podratz
Oct 9, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B M SoodG L Goldberg
Dec 13, 2002·Gynecologic Oncology·Rachel KupetsAllan Covens
Feb 22, 2003·Current Treatment Options in Oncology·D Scott McMeekin, Todd Tillmanns
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R E BristowF J Montz
Feb 27, 2004·Gynecologic Oncology·Andrea MarianiKarl C Podratz
Aug 30, 2005·Gynecologic Oncology·Laura J HavrileskyAndrew Berchuck

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Citations

Jul 19, 2013·Obstetrics and Gynecology International·Helen E DinkelspielThomas J Herzog
Jun 28, 2014·Annals of Surgical Oncology·Sofiane BendifallahMarcos Ballester
Jul 9, 2010·Obstetrics and Gynecology International·R SeracchioliS Venturoli
Mar 7, 2008·Annals of Surgical Oncology·Marcos BallesterEmile Darai
Dec 8, 2010·Annals of Surgical Oncology·Seo-Yun TongKi-Tae Kim
Apr 21, 2012·Obstetrics and Gynecology International·Mohamed K Mehasseb, John A Latimer
Jul 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D C SmithD K Gaffney
Feb 16, 2013·International Journal of Clinical Oncology·Mariam M AlHilli, Andrea Mariani
Mar 7, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C-Y HuangW-F Cheng
Jan 10, 2016·Journal of Cancer Research and Clinical Oncology·Holm EggemannAtanas Ignatov
Mar 1, 2011·Surgical Pathology Clinics·Mario M Leitao, Richard R Barakat
Jan 30, 2010·Gynecologic Oncology·Leigh G SeamonDavid E Cohn
Jan 2, 2009·Gynécologie, obstétrique & fertilité·C Nadeau, G Magnin
Dec 27, 2008·Gynécologie, obstétrique & fertilité·F NarducciE Leblanc
Feb 5, 2008·Gynecologic Oncology·James W OrrPedro Escobar
Sep 4, 2007·The Lancet Oncology·John K Chan, Daniel S Kapp
Sep 27, 2015·Gynecologic Oncology·Katherine A O'HanlanStacey P McCutcheon
Dec 18, 2012·Histopathology·Lynn HirschowitzRichard J Zaino
Jan 30, 2014·The Journal of Obstetrics and Gynaecology Research·Giorgio BoganiAndrea Mariani
May 21, 2015·Archives of Gynecology and Obstetrics·Christina FotopoulouFlorian Heitz
May 17, 2006·Gynecologic Oncology·David Scott Miller
Apr 9, 2008·American Journal of Obstetrics and Gynecology·Nadeem R Abu-RustumRichard R Barakat
Nov 6, 2013·Obstetrics and Gynecology International·Fabien Vidal, Arash Rafii
Sep 1, 2009·Gynecologic Oncology·Anthony H Russell
May 10, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ahmet PadakSeyran Yiğit
Mar 10, 2009·Gynecologic Oncology·Joseph T SantosoTodd D Tillmanns
Jun 24, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Angiolo GadducciAndrea Riccardo Genazzani
Dec 9, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiFabio Ghezzi
May 14, 2011·The American Journal of Surgical Pathology·Elizabeth D EuscherAnais Malpica
Jul 11, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Fabien VidalArash Rafii
Mar 23, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Supratik ChattopadhyayRaj Naik
Jan 7, 2009·Current Opinion in Obstetrics & Gynecology·Toshio FujimotoToshinobu Tanaka
May 2, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Helena RobovaLukas Rob
May 2, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F H van WijkH C van Doorn
Jul 1, 2008·Expert Review of Anticancer Therapy·Jessica L FiorelliJason D Wright
Dec 4, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggageLynn Hirschowitz
Dec 4, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Francesco LeggeFrancesco Fanfani
Jul 22, 2010·Expert Review of Anticancer Therapy·Jonathan FeddockMarc Randall
Jul 11, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiAndrea Mariani

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