Abstract
Immunotherapy is an ideal treatment modality to specifically target the diffusely infiltrative tumor cells of malignant gliomas while sparing the normal brain parenchyma. However, progress in the development of these therapies for glioblastoma has been slow due to the lack of immunogenic antigen targets that are expressed uniformly and selectively by gliomas. We utilized human glioblastoma cell cultures to induce expression of New York-esophageal squamous cell carcinoma (NY-ESO-1) following in vitro treatment with the demethylating agent decitabine. We then investigated the phenotype of lymphocytes specific for NY-ESO-1 using flow cytometry analysis and cytotoxicity against cells treated with decitabine using the xCelligence real-time cytotoxicity assay. Finally, we examined the in vivo application of this immune therapy using an intracranially implanted xenograft model for in situ T cell trafficking, survival, and tissue studies. Our studies showed that treatment of intracranial glioma-bearing mice with decitabine reliably and consistently induced the expression of an immunogenic tumor-rejection antigen, NY-ESO-1, specifically in glioma cells and not in normal brain tissue. The upregulation of NY-ESO-1 by intracranial gliomas ...Continue Reading
References
Apr 2, 2002·Journal of Immunotherapy·Lisa M GuirguisDouglas J Schwartzentruber
Jun 5, 2002·Journal of Neuroimmunology·Sarah FlorisHelga E De Vries
Aug 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda M LiauMichael D Roth
Mar 11, 2006·Cancer Genetics and Cytogenetics·German G GomezCarol A Kruse
Sep 2, 2006·Science·Richard A MorganSteven A Rosenberg
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Feb 2, 2008·International Journal of Cancer. Journal International Du Cancer·Atsushi NatsumeJun Yoshida
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul F RobbinsSteven A Rosenberg
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E DudleySteven A Rosenberg
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Duane A Mitchell, John H Sampson
Jan 13, 2010·The Journal of Experimental Medicine·Sadna BudhuSamuel C Silverstein
Oct 19, 2010·Clinical & Developmental Immunology·Elodie VauleonVéronique Quillien
Dec 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert M PrinsLinda M Liau
Feb 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul F RobbinsSteven A Rosenberg
Jul 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher A KlebanoffNicholas P Restifo
Nov 9, 2011·Journal of Translational Medicine·Veerauo V KonkankitRobert M Prins
Feb 5, 2013·Journal of Immunotherapy·Richard A MorganSteven A Rosenberg
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Jul 28, 2013·Biomedical Microdevices·G RamisA Muñoz
Apr 23, 2015·Biomedical Journal·Florian C Kurschus
Citations
Oct 16, 2015·Molecular Medicine Reports·Dong LiXiao-Guang Yu
Feb 28, 2016·Stem Cell Research·Vivian Capilla-GonzalezAlfredo Quiñones-Hinojosa
Dec 21, 2016·Immunotherapy·Shigeo KoidoHaruo Sugiyama
Mar 17, 2017·World Neurosurgery·Alice L HungMichael Lim
Apr 17, 2017·Current Opinion in Genetics & Development·Andrew D Kelly, Jean-Pierre J Issa
Jan 25, 2017·Neuro-oncology·Joseph P AntoniosRobert M Prins
Jul 15, 2016·Molecular & Cellular Proteomics : MCP·Bracha ShraibmanArie Admon
Mar 11, 2018·Molecular Neurobiology·Vishal Jindal
Mar 3, 2018·PloS One·Fabio CerignoliBiao Xi
Aug 30, 2019·Journal for Immunotherapy of Cancer·Qin TanZheming Lu
Jan 5, 2020·Immunologic Research·In Hye SongHee Jin Lee
Oct 24, 2017·Cancer Immunology, Immunotherapy : CII·Zhenjiang LiuMarkus Maeurer
Sep 1, 2016·PloS One·Cristina RiccadonnaPaul R Walker
Sep 1, 2016·Oncotarget·Layale YaghiPhilippe Moreau
May 18, 2016·World Journal of Gastroenterology : WJG·Mikio KajiharaShigeo Koido
Nov 6, 2018·Frontiers in Oncology·Anna C FilleyMahua Dey
Dec 21, 2018·Frontiers in Oncology·John LynesEdjah Nduom
Mar 30, 2020·Journal of Translational Medicine·Afsheen RazaSaid Dermime
May 11, 2017·Current Neurology and Neuroscience Reports·Russell MaxwellMichael Lim
Oct 28, 2019·Cancers·Jong-Whi Park, Şevin Turcan
Aug 5, 2020·The Journal of Clinical Investigation·Corey SmithRajiv Khanna
Oct 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A BraunEliezer M Van Allen
Jun 25, 2021·Frontiers in Immunology·Concetta QuintarelliBiagio De Angelis