Efficacy of tacrolimus rescue therapy in refractory acute rejection after lung transplantation

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
P VituloMario Viganò

Abstract

Encouraging results in transplantation of other solid organs led to investigation of the use of tacrolimus in lung transplantation as a salvage immunosuppressant in persistent acute rejection. The incidence and severity of acute rejection and the number of steroid pulses were analyzed in 20 lung recipients who were converted from a cyclosporine- to a tacrolimus-based immunosuppressive regimen because of refractory biopsy-proven acute rejection. Tacrolimus was started 12.0 +/- 13.0 months after transplantation, and the mean follow-up was 25.0 +/- 13.7 months. After shifting to tacrolimus, a significant decline was observed in both the number of acute rejections per patient (3.0 +/- 1.56 to 0.85 +/- 1.14, p < 0.0001), and the incidence of acute rejection per 100 patient-days (1.52 +/- 0.99 to 0.14 +/- 0.21, p < 0.0001). Furthermore, the average histologic grade of rejection decreased from 1.9 +/- 0.8 to 0.4 +/- 0.5 (p < 0.0001). Methylprednisolone pulses similarly decreased from 1.9 +/- 1.3/patient to 0.3 +/- 0.7/patient (p < 0.0001). During cyclosporine immunosuppression, the mean forced expiratory volume in 1 second decreased to 84.4% +/- 13.3% of individual best value. The average lung function parameters were stable 3 months ...Continue Reading

Associated Clinical Trials

References

Sep 1, 1995·The Annals of Thoracic Surgery·R J KeenanB P Griffith
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Jun 24, 1998·Transplantation Proceedings·D A LipsonJ Edelman
Jun 24, 1998·Transplantation Proceedings·K WiebeA Haverich
May 21, 1999·Thorax·J W van den BergW van der Bij
Jun 11, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D R OnsagerR B Love
Aug 12, 1999·The Thoracic and Cardiovascular Surgeon·F KurB Reichart
Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M H YamaniJ B Young
Dec 20, 2000·Transplantation Proceedings·H J JangD J Han

❮ Previous
Next ❯

Citations

Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Regine RagetteHeinz Jakob
Mar 26, 2004·Transplantation Proceedings·A Zuckermann, W Klepetko
Sep 10, 2003·Transplantation Proceedings·R LamaC Baamonde
Jun 18, 2004·Transplantation·Edward R Garrity, Mandeep R Mehra
Jan 10, 2009·Proceedings of the American Thoracic Society·Tereza MartinuScott M Palmer
Apr 23, 2011·Clinics in Chest Medicine·Tereza MartinuScott M Palmer
Oct 11, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B D ReamsS M Palmer
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David ShitritMordechai R Kramer
Mar 16, 2007·Expert Opinion on Emerging Drugs·Babith MankidyHarish Seethamraju
Mar 26, 2004·Transplantation Proceedings·K ParekhG A Patterson
Apr 9, 2004·Journal of Intensive Care Medicine·Christine L LauScott M Palmer
Jul 7, 2019·La Radiologia medica·Ambra Di PiazzaRoberto Miraglia
Jul 24, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Sophie C van der MarkMerel E Hellemons
Jun 20, 2018·Drugs·Steven IvulichGregory Snell
Dec 4, 2002·Annals of Plastic Surgery·Delphine L ChenAaron G Grand
May 4, 2021·Current Opinion in Organ Transplantation·Lorenzo Zaffiri
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Benjamin Renaud-PicardTereza Martinu
May 20, 2021·Current Opinion in Organ Transplantation·Lorenzo Zaffiri
Apr 18, 2003·Critical Care Clinics·Behnam M Goudarzi, Steven Bonvino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
J CairnM Yacoub
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
H TreedeMunich and Vienna Lung Transplant Group
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
D R OnsagerR B Love
Transplant International : Official Journal of the European Society for Organ Transplantation
Kambiz SarahrudiWalter Klepetko
© 2022 Meta ULC. All rights reserved