PMID: 9438653Jan 23, 1998Paper

Efficacy of taxol in the orpk mouse model of polycystic kidney disease

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
C S SommardahlJ E Wilkinson

Abstract

Polycystic kidney disease (PKD) a is common disease in the human population that can lead to renal failure and death. Taxol has recently been reported to be of therapeutic benefit in the cpk mouse model of PKD. To determine whether these results also apply to other models of PKD, we studied the effects of taxol treatment on the development of renal cysts and biliary hyperplasia/dysplasia/fibrosis in the orpk mouse mutant, a unique murine model for human autosomal recessive PKD. We report no significant differences between the treatment and control groups with respect to weight gain, survival, urine to serum osmolality ratio, and serum concentration of liver enzymes. Moreover, renal cystic development was not affected by taxol treatment in the orpk mutant animals. This was confirmed by lectin staining and morphometric analysis of the renal cysts, which indicated no significant differences between treatment groups. Therefore, while taxol has a positive effect on the cystic kidney disease in cpk mutant mice, this effect is not applicable to all forms of PKD.

Citations

Jun 15, 2006·Molecular Diagnosis & Therapy·Carsten BergmannKlaus Zerres
Jun 7, 2011·Acta Pharmacologica Sinica·Ying SunBao-xue Yang
May 31, 2001·Kidney International·Q QianV E Torres
Feb 21, 2002·The Journal of Clinical Investigation·Xiaoying HouLisa M Guay-Woodford
Feb 17, 2006·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Bernardo Barahona CorrêaJoão Guimarães
Jul 30, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gisela G SlaatsRachel H Giles
Dec 7, 2006·The American Journal of Pathology·Miliyun G ChiuPaul J D Winyard
Jun 19, 2004·The International Journal of Biochemistry & Cell Biology·Patricia D Wilson
Dec 13, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L F Menezes, L F Onuchic
Jun 7, 2012·Korean journal of urology·Saied Karbalay-DoustSeyed-Mohammad Pourshahid
May 18, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerd Walz
Feb 22, 2001·American Journal of Physiology. Renal Physiology·N ObermüllerR Witzgall
Nov 6, 2003·American Journal of Physiology. Renal Physiology·Lisa M Guay-Woodford
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Peter Igarashi, Stefan Somlo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.