Efficacy of thalidomide for the treatment of amyotrophic lateral sclerosis: a phase II open label clinical trial.

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Elijah W StommelBrent T Harris

Abstract

Neuroinflammation through the cytokine, tumor necrosis factor-alpha (TNF-alpha) is thought to play an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). We conducted a preliminary phase II trial of thalidomide, which reduces levels of TNF-alpha pre-transcriptionally and post-transcriptionally in vivo and has been shown to prolong disease duration and extend the lifespan of transgenic animal models of ALS. Patients who met diagnostic criteria for ALS received thalidomide at escalating doses to a target dose of 400 mg/day. The primary endpoints in the trial were the ALS Functional Rating Scale (ALSFRS) and pulmonary function testing (PFT) curves after nine months of thalidomide treatment that were compared to historical controls. Secondary endpoints were: survival stratified for newly diagnosed and progressive disease, toxicity, quality of life, and serum cytokine measurements. Twenty-three patients were enrolled, but only 18 were evaluable for the primary outcome. There was no improvement in the ALSFRS or PFT compared to historical controls. Thalidomide had several side-effects in our ALS patients. There was no significant shift in cytokine profile after treatment compared to baseline. In conclusion, trea...Continue Reading

References

May 1, 1979·Journal of the Neurological Sciences·H TsukagoshiT Murakami
Jun 1, 1993·The Journal of Experimental Medicine·A L MoreiraG Kaplan
Oct 1, 1996·Neurology·A Hirano
Aug 1, 1996·Journal of the Neurological Sciences·D SchifferA Migheli
Nov 1, 2001·Brain Research. Molecular Brain Research·J L Elliott
Mar 27, 2002·Neurology·Paul Alan Cox, Oliver W Sacks
Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·A Aggarwal, G Nicholson
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Aug 27, 2003·Neurology·M E CudkowiczUNKNOWN Northeast ALS Consortium
Feb 8, 2005·European Journal of Haematology·Patrizia TosiMichele Cavo
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mahmoud KiaeiM Flint Beal
Oct 4, 2006·Neuron·Séverine BoilléeDon W Cleveland
Oct 20, 2006·Journal of the Neurological Sciences·Susanne PetriM Flint Beal
Nov 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Geneviève GowingJean-Pierre Julien
Jan 4, 2007·Neurology·M Muddasir QureshiElizabeth Raynor
Jun 6, 2007·Neurology·Fumiharu Kimura
Sep 14, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Michael RentzosDemetrios Vassilopoulos
Dec 18, 2007·Journal of Neuroimmunology·Cristina CeredaMauro Ceroni
Apr 22, 2008·Journal of Neurology·Thomas MeyerPeter Linke
Jul 29, 2008·Journal of Neuro-oncology·Camilo E FadulJ Marc Pipas

❮ Previous
Next ❯

Citations

Jun 17, 2010·Journal of Neural Transmission·Ana G BarbeitoSéverine Boillée
Jul 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hiroyuki FukazawaSeiitsu Ono
Feb 1, 2011·International Journal of Human-computer Interaction·D B RyanE W Sellers
Aug 7, 2012·The Journal of Clinical Investigation·Oleg ButovskyHoward L Weiner
Oct 9, 2013·Cellular and Molecular Life Sciences : CMLS·Federica RizzoEva Hedlund
Jun 27, 2014·Mediators of Inflammation·Gabriel Olmos, Jerònia Lladó
Jul 26, 2012·Neurology Research International·Kalina Venkova-HristovaKenneth Hensley
Aug 3, 2011·Expert Opinion on Emerging Drugs·Ali Aamer Habib, Hiroshi Mitsumoto
Feb 7, 2012·Expert Opinion on Investigational Drugs·John A Morren, Nestor Galvez-Jimenez
Dec 23, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·UNKNOWN ALSUntangled Group
Nov 1, 2013·Drug Discovery Today·Bariş Genç, P Hande Özdinler
Jun 12, 2014·Journal of Neuropathology and Experimental Neurology·Nilo RivaAngelo Quattrini
Aug 9, 2015·Progress in Neurobiology·Renzo Mancuso, Xavier Navarro
Dec 3, 2015·Surgical Neurology International·Sara ZareiAngel Chinea
Sep 2, 2014·Brain Research·Michael JablonskiDavide Trotti
Sep 11, 2014·Drug Discovery Today·Yongjin ZhuXin Wang
Mar 26, 2013·Biochimica Et Biophysica Acta·Philip McGoldrickLinda Greensmith
Jul 4, 2016·European Journal of Medicinal Chemistry·Vijay KumarFaizan Ahmad
Feb 27, 2017·Journal of Molecular Neuroscience : MN·Giovanna MorelloSebastiano Cavallaro
Oct 3, 2018·Expert Review of Neurotherapeutics·Arens Taga, Nicholas J Maragakis
Jul 19, 2013·Cellular and Molecular Life Sciences : CMLS·Rachna S PandyaXin Wang
Feb 12, 2020·Medicinal Research Reviews·Heike J WobstJames Shorter
Jun 3, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·I GiovannelliJ Kirby
Oct 11, 2017·Frontiers in Neurology·Syed I KhalidChristopher Dardis
Jun 15, 2019·International Journal of Molecular Sciences·Laura Moreno-MartinezRosario Osta
Mar 4, 2020·Neurology. Neuroimmunology and Neuroinflammation·Mads Nikolaj OlesenNasrin Asgari
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Michael BenatarDan H Moore
Oct 31, 2017·Mediators of Inflammation·Massimo TortaroloCaterina Bendotti
Feb 24, 2018·Frontiers in Neurology·Marcelo R S BrionesJames R Broach
Dec 24, 2019·Frontiers in Cell and Developmental Biology·Yoo Jin JungNigel H Greig
Jan 1, 2013·Journal of Neurodegenerative Diseases·Julianne AebischerCédric Raoul
Jun 28, 2017·Journal of Neuroinflammation·Javier H JaraP Hande Özdinler
Nov 20, 2012·Current Opinion in Neurology·Matthew GladmanLorne Zinman
Dec 10, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lucas T Vu, Robert Bowser
Aug 28, 2020·Neurochemistry International·Dia AdvaniPravir Kumar
Jul 3, 2021·International Journal of Molecular Sciences·Christine Péladeau, Jagdeep K Sandhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.