Efficacy of the hatching event in assessing the embryo toxicity of the nano-sized TiO₂ particles in zebrafish: a comparison between two different classes of hatching-derived variables

Ecotoxicology and Environmental Safety
Seyed-Mohammadreza SamaeeVahid Haghpanah

Abstract

The aim of the present study was to evaluate the nano-TiO2 toxicity to zebrafish embryos through evaluating the success in hatching in relationship with hours post-exposure instead of considering just the total hatching rate. Zebrafish embryos 4h post-fertilization were exposed to nTiO2 (0, 0.01, 10, and 1000 µg mL(-1)) for 130 h. The hatching rate (HR) was calculated for each concentration (treatment). The HR magnitude was significantly (p<0.001) correlated (using simple regression) to hours post-exposure time interval (hpe; 34, 58, 82, 106, and 130), noted as HR.hpe. The HR descriptive statistics (HRds) and the parameters of the regression models (i.e., constant, x, F, and r(2)) were recruited to define 15 HRds- and 4 h.hpe-derived variables, respectively. The efficacy of the variables was evaluated. Exposure to nTiO2 led to a significant: premature hatching and general decrease in time required for normal hatching; and change in HR and hpe interrelations in a dose-dependent manner. The major change in hatchability between the treatment and control occurred at 58 hpe (62 hpf), when the treatment with nTiO2 induced significant premature hatching compared to only 6% of the hatched embryos in the control at the same time point. ...Continue Reading

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Citations

Aug 22, 2016·Journal of Nanobiotechnology·Chiranjib ChakrabortySang-Soo Lee
Jul 6, 2017·Zebrafish·Seyed-Mohammadreza SamaeeBahman Rezaei
Sep 6, 2018·Environmental Toxicology and Chemistry·Seyed-Mohammadreza SamaeeMohammad Reza Mohajeri-Tehrani
Dec 31, 2019·Journal of Applied Toxicology : JAT·Changcun Bai, Meng Tang
Jul 20, 2019·Particle and Fibre Toxicology·Jinsoo LeeWook-Joon Yu
Jun 17, 2020·Toxicology and Industrial Health·Zengjin Wang, Zhiping Wang
Jul 26, 2018·Nanomaterials·Enamul Haque, Alister C Ward
Dec 11, 2020·Drug and Chemical Toxicology·Jiazhen WangQiuxia He
Dec 17, 2019·The Science of the Total Environment·Bojan NatarajMathan Ramesh
Jan 23, 2021·The Science of the Total Environment·Hai LinJie Chen
Dec 8, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mine KöktürkMehmet Salih Nas
Apr 10, 2018·The Science of the Total Environment·Le QianChengju Wang
Aug 24, 2021·Nanoscale Research Letters·Suraiya Saleem, Rajaretinam Rajesh Kannan
Oct 5, 2021·Autism Research : Official Journal of the International Society for Autism Research·Thomson Patrick JosephMelitta Schachner

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