Efficacy of theta burst stimulation (TBS) for major depression: An exploratory meta-analysis of randomized and sham-controlled trials

Journal of Psychiatric Research
Marcelo T BerlimRuben Martins

Abstract

Theta burst stimulation (TBS) has been proposed as a novel treatment for major depression (MD). However, randomized and sham-controlled trials (RCTs) published to date have yielded heterogeneous clinical results and we have thus carried out the present systematic review and exploratory meta-analysis of RCTs to evaluate this issue. We searched the literature for RCTs on TBS for MD from January 2001 through September 2016 using MEDLINE, EMBASE, PsycINFO, and CENTRAL. We then performed a random-effects meta-analysis with the main outcome measures including pre-post score changes in the Hamilton Depression Rating Scale (HAM-D) as well as rates of response, remission and dropout. Data were obtained from 5 RCTs, totalling 221 subjects with MD. The pooled Hedges' g for pre-post change in HAM-D scores was 1.0 (p = 0.003), indicating a significant and large-sized difference in outcome favouring active TBS. Furthermore, active TBS was associated with significantly higher response rates when compared to sham TBS (35.6% vs. 17.5%, respectively; p = 0.005), although the groups did not differ in terms of rates of remission (18.6% vs. 10.7%, respectively; p = 0.1) and dropout (4.2% vs. 7.8%, respectively; p = 0.5). Finally, subgroup analyses ...Continue Reading

Citations

Jul 20, 2018·The European Journal of Neuroscience·Ruben Perellón-AlfonsoMaja Kojovic
Jul 10, 2019·Expert Review of Neurotherapeutics·Leo ChenPaul B Fitzgerald

May 3, 2019·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Daniel C Kopala-SibleyAlexander McGirr
Jul 9, 2020·Frontiers in Human Neuroscience·Marc PalausElena M Marrón
May 22, 2020·Frontiers in Neuroscience·James Z FanSunil A Sheth
Jan 7, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurUlf Ziemann
Aug 26, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Travis E BakerSeema Parikh
Jun 4, 2019·La Presse médicale·Samuel BulteauAnne Sauvaget
Jul 10, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Amitabh BhattacharyaKaviraja Udupa

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