Efficacy of Tiotropium/Olodaterol Compared with Tiotropium as a First-Line Maintenance Treatment in Patients with COPD Who Are Naïve to LAMA, LABA and ICS: Pooled Analysis of Four Clinical Trials.

Advances in Therapy
Roland BuhlGary T Ferguson

Abstract

The efficacy of tiotropium/olodaterol compared with tiotropium in patients with chronic obstructive pulmonary disease (COPD) has been demonstrated in a large clinical programme. Currently, randomised controlled trial (RCT) data on dual bronchodilation as first-line maintenance therapy are limited. In this post hoc analysis of pooled data from four RCTs, we compared the efficacy of tiotropium/olodaterol versus tiotropium as maintenance therapy in patients with COPD who were not receiving maintenance treatment with long-acting muscarinic antagonists (LAMAs), long-acting β2-agonists (LABAs) or inhaled corticosteroids (ICS) ("maintenance naïve") at study entry. TONADO® 1/2 (52 weeks) and OTEMTO® 1/2 (12 weeks) were phase III RCTs in patients with COPD. TONADO 1/2 and OTEMTO 1/2 enrolled patients with post-bronchodilator forced expiratory volume in 1 s (FEV1) < 80% predicted (lower limit FEV1 ≥ 30% in OTEMTO 1/2 only). We examined the effect of tiotropium/olodaterol 5/5 µg versus tiotropium 5 µg on trough FEV1 response, St. George's Respiratory Questionnaire (SGRQ) total score and Transition Dyspnoea Index (TDI) focal score at 12 weeks in four pooled studies. The pooled analysis included 1078 maintenance-naïve patients. There were s...Continue Reading

References

Mar 1, 2003·The European Respiratory Journal·T J Witek, D A Mahler
Mar 1, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Claudio Tantucci, Denise Modina
Jan 5, 2014·American Journal of Respiratory and Critical Care Medicine·Paul W JonesJadwiga A Wedzicha
Mar 14, 2014·The Lancet. Respiratory Medicine·Paul W Jones
Jan 13, 2015·The European Respiratory Journal·Roland BuhlEric Bateman
Sep 1, 2015·Respiratory Medicine·Dave SinghLeif Bjermer
Jan 18, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Luigino CalzettaMaria Gabriella Matera
Apr 1, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Gustavo J RodrigoKonstantinos Kostikas
Apr 23, 2017·Respiratory Research·Marc Miravitlles, Anna Ribera
Apr 18, 2018·American Journal of Respiratory and Critical Care Medicine·Thierry TroostersJean Bourbeau
Dec 28, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Kate M JohnsonUNKNOWN Canadian Respiratory Research Network
Jun 20, 2019·International Journal of Chronic Obstructive Pulmonary Disease·Yilan Sun, Jianying Zhou
Jul 25, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shigeo MuroJadwiga A Wedzicha
Sep 27, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Dave Singh
Apr 15, 2020·American Journal of Respiratory and Critical Care Medicine·Linda NiciShawn D Aaron

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Citations

Jan 21, 2021·Drug Design, Development and Therapy·Liu-Cheng LiLian-Di Kan
Aug 21, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Dave SinghFernando J Martinez

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