Efficacy of topical Citrullus colocynthis (bitter apple) extract oil in chemotherapy-induced peripheral neuropathy: A pilot double-blind randomized placebo-controlled clinical trial

Phytotherapy Research : PTR
Nematollah RostamiMojtaba Heydari

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common complications in patients with cancer. Citrullus colocynthis (bitter apple) has been used in traditional Persian medicine as an effective pain relief, especially for neuralgia. We designed a pilot clinical trial to evaluate the safety and efficacy of topical C. colocynthis oil in management of CIPN in breast cancer patients. Thirty-four cancer patients with CIPN were randomly enrolled in two arms of a randomized, double-blind, placebo-controlled clinical trial. The patients were treated by topical C. colocynthis oil or placebo, two times per day for 2 months. Functional Assessment of Cancer Therapy/Gynecologic Oncology Group (FACT/GOG)-Neurotoxicity (Ntx) score was set as the primary outcome measure. No significant improvement was observed in the total score of FACT/GOG-Ntx scale (2.40 ± 1.90 vs. 1.05 ± 1.36, p = .879) in drug and placebo groups, respectively. There was also no significant improvement in the mean scores of FACT/GOG-Ntx in the sensory, motor, hearing, and functional domains in the two study groups. According to the results of this preliminary study, topical C. colocynthis oil failed to improve the symptoms of CIPN compared with placebo.

References

Jan 14, 2009·Molecular Cancer Therapeutics·Sarah R McWhinneyHoward L McLeod
Sep 13, 2011·Critical Reviews in Oncology/hematology·Andreas A ArgyriouGuido Cavaletti
Jul 13, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Roja RahimiMohammad Reza Shams Ardekani
Apr 4, 2013·JAMA : the Journal of the American Medical Association·Ellen M Lavoie SmithUNKNOWN Alliance for Clinical Trials in Oncology
Dec 20, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jennifer Piccolo, Jill M Kolesar
Jan 5, 2014·Frontiers in Pharmacology·Yaqin Han, Maree T Smith
Feb 27, 2015·Journal of Complementary & Integrative Medicine·Farzad ShidfarShahrzad Shidfar
Apr 8, 2015·Critical Reviews in Food Science and Nutrition·Janet SchlossLuis Vitetta
Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Ali Shahriari-AhmadiMasoud Sadeghi
Dec 5, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Saeed MehrzadiManijeh Motevalian
Dec 15, 2015·Critical Reviews in Oncology/hematology·Cloé BramiGary Deng
Dec 10, 2016·British Journal of Clinical Pharmacology·Pietro MinuzAlbert Ferro
Jan 18, 2017·Phytotherapy Research : PTR·Akash TariqMuhammad Adnan
Jan 22, 2017·Complementary Therapies in Clinical Practice·Mohammad Hashem HashempurArman Zargaran
Jan 31, 2017·Nature Reviews. Endocrinology·Paola M Hunter, Robert A Hegele
May 14, 2017·British Journal of Pharmacology·Ruth Andrew, Angelo A Izzo
Dec 13, 2017·Journal of Evidence-based Complementary & Alternative Medicine·Abolfazl AkbariAida Iraji
Mar 20, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Afsaneh ShakeriFatemeh Nejatbakhsh
Apr 11, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Hyeonseok NohBongki Park
Aug 15, 2018·Cancer Chemotherapy and Pharmacology·Negin FarshchianNasrin Moradian

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Citations

Sep 15, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ghazaleh HeydariradMehdi Pasalar
Oct 11, 2020·Journal of Cancer Research and Clinical Oncology·Judith BüntzelJens Büntzel

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