Efficacy of topical N-acetylcysteine in the treatment of meibomian gland dysfunction

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Ilknur Akyol-SalmanOrhan Baykal

Abstract

To evaluate the efficacy of topical N-acetyl-cysteine (NAC) therapy in patients with meibomian gland dysfunction (MGD). Twenty patients with MGD were prospectively randomized and assigned into 2 groups. The patients were instructed to use either NAC 5% or preservative-free artificial tear topically 4 times a day for a month. All patients were instructed to apply lid hygiene once daily. Preservative-free artificial tears treated group served as control. Paired sample Student's t-tests were used to detect differences between the baseline and 1 month after treatment initiation in mean ocular symptoms, fluorescein break-up time (FBUT) values, and Schirmer scores in each group. Difference in mean ocular symptoms, Schirmer's test scores, and FBUT values between the baseline and 1 month after treatment initiation were compared between the groups using Mann-Whitney U test. One month of topical NAC therapy provided statistically significant improvements in FBUT and Schirmer scores as compared with the initial study visit. The average Schirmer increase rate was significantly better in the NAC group than in the control group. Significant improvements for the symptoms of ocular burning, foreign body sensation, and intermittent filmy or blu...Continue Reading

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Citations

Jul 15, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ilknur Akyol-SalmanOrhan Baykal
Jul 3, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jonathan N KruhC Stephen Foster
Aug 21, 2014·The British Journal of Ophthalmology·Mohsen Bahmani KashkouliLeila Ghiasian
Jun 13, 2015·Systematic Reviews·Mohamed Farouk ChughlayKaren Cohen
Jan 13, 2016·British Journal of Clinical Pharmacology·Mohamed Farouk ChughlayKaren Cohen
Jan 14, 2017·International Journal of Dermatology·Israel Pérez-LopezJesús Tercedor-Sánchez
Feb 17, 2019·Rheumatology·Elizabeth J Price, Alan N Baer
Jan 2, 2018·The Open Ophthalmology Journal·Kannan Sridharan, Gowri Sivaramakrishnan
May 18, 2012·The Cochrane Database of Systematic Reviews·Kristina LindsleyEsen K Akpek
Jun 1, 2016·Eye & Contact Lens·Yousef A AlghamdiAnat Galor
Sep 11, 2020·Journal of Ophthalmology·Fidelina ParraEleazar Lara-Padilla
Mar 12, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·P MaierT Reinhard
Jul 19, 2011·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ilknur Akyol-SalmanOrhan Baykal
Sep 29, 2017·Rheumatology·Elizabeth J PriceUNKNOWN British Society for Rheumatology Standards, Guideline and Audit Working Group
Nov 25, 2018·Progress in Retinal and Eye Research·Christophe BaudouinMarc Labetoulle
May 28, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Andrew J Crist
Jul 3, 2021·Antioxidants·Micaely Cristina Dos Santos TenórioMarília Oliveira Fonseca Goulart
Aug 3, 2021·Survey of Ophthalmology·Yas EghtedariStephanie L Watson

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