Efficacy of topical photodynamic therapy for keratoacanthomas: a case-series of four patients

Indian Journal of Dermatology, Venereology and Leprology
Maria M FariasSergio Gonzalez

Abstract

Topical photodynamic therapy (PDT) is an excellent treatment option for various non-melanoma skin cancers and precancerous lesions, including actinic keratosis, Bowen's disease, and basal cell carcinoma. The clinical use of PDT includes a broad range of neoplastic, inflammatory, and infectious skin diseases. There is also anecdotal evidence suggesting the efficacy of PDT for the treatment of keratoacanthomas (KA). We report a case-series of four patients with solitary KA confirmed by histology, treated with topical PDT with methylaminolevulinic acid (MAL) cream. After three sessions of PDT, the lesions completely disappeared. There was no evidence of recurrence and excellent cosmetic outcome was achieved after three years of follow-up. Topical photodynamic therapy with MAL can be a therapeutic alternative for KA with good clinical and cosmetic outcomes.

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Related Concepts

Metvix
Administration, Topical
Aminolevulinic Acid Hydrochloride
Keratoacanthoma
Photochemotherapy
Dermatologic Disorders
Photosensitizing Effect
Acids
Bowen's Disease
Malignant Neoplasm of Skin

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Bowen's Disease

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Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

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