Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection.

Blood
Thomas H PriceSusan F Assmann

Abstract

High-dose granulocyte transfusion therapy has been available for 20 years, yet its clinical efficacy has never been conclusively demonstrated. We report here the results of RING (Resolving Infection in Neutropenia with Granulocytes), a multicenter randomized controlled trial designed to address this question. Eligible subjects were those with neutropenia (absolute neutrophil count <500/μL) and proven/probable/presumed infection. Subjects were randomized to receive either (1) standard antimicrobial therapy or (2) standard antimicrobial therapy plus daily granulocyte transfusions from donors stimulated with granulocyte colony-stimulating factor (G-CSF) and dexamethasone. The primary end point was a composite of survival plus microbial response, at 42 days after randomization. Microbial response was determined by a blinded adjudication panel. Fifty-six subjects were randomized to the granulocyte arm and 58 to the control arm. Transfused subjects received a median of 5 transfusions. Mean transfusion dose was 54.9 × 10(9) granulocytes. Overall success rates were 42% and 43% for the granulocyte and control groups, respectively (P > .99), and 49% and 41%, respectively, for subjects who received their assigned treatments (P = .64). Suc...Continue Reading

References

Sep 1, 1976·The Journal of Clinical Investigation·J T DanceyC A Finch
Sep 1, 1974·Journal of Chronic Diseases·M Zelen
Nov 1, 1980·Annals of Internal Medicine·D J WinstonR P Gale
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
May 14, 1981·The New England Journal of Medicine·D G WrightA B Deisseroth
Dec 1, 1996·Australian and New Zealand Journal of Medicine·A GriggJ Szer
Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jo-Anne H van BurikUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group
Apr 20, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lorenz GrigullHans-Gert Heuft
Jan 26, 2007·The New England Journal of Medicine·Andrew J UllmannSimon Durrant
Jan 26, 2007·The New England Journal of Medicine·Oliver A CornelyDavid Angulo-Gonzalez
Oct 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eyal RobenshtokMical Paul
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Aug 13, 2008·Bone Marrow Transplantation·M G SeidelH Einsele
Nov 13, 2013·Expert Opinion on Investigational Drugs·Ze-Qi XuJohn Flavin
Jul 2, 2014·Clinical Microbiology Reviews·Marios ArvanitisEleftherios Mylonakis
Dec 17, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Arianna Miles-JaySteven A Pergam
Jan 20, 2015·Annals of Internal Medicine·Kieren A MarrJohan A Maertens

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Citations

Apr 27, 2016·Hematology/oncology Clinics of North America·Rachel S Bercovitz, Cassandra D Josephson
Oct 21, 2016·Transfusion Medicine·T CreaseyM Collin
Jul 2, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas F PattersonJohn E Bennett
Mar 28, 2017·The Journal of Allergy and Clinical Immunology·Beatriz E MarcianoSergio D Rosenzweig
Apr 4, 2017·British Journal of Haematology·Maria-Teresa Cutino-MoguelDarius Armstrong-James
Apr 22, 2017·Expert Opinion on Biological Therapy·Wilfried PoschCornelia Lass-Flörl
May 17, 2017·Current Opinion in Infectious Diseases·Tobias M Hohl
Jan 27, 2018·Journal of Fungi·Linda DavidsonBart Jan Kullberg
Dec 14, 2017·Annual Review of Immunology·Michail S Lionakis, Stuart M Levitz
Aug 24, 2017·Transfusion Medicine·S MortonS J Stanworth
Jul 18, 2018·Pediatric Transplantation·Caitlin W ElgartenJason L Freedman
Apr 30, 2016·The Cochrane Database of Systematic Reviews·Lise J EstcourtEdwin Massey
Oct 17, 2018·Internal Medicine Journal·Danielle B ClucasUNKNOWN Australian Aplastic Anaemia Registry Steering Committee
May 19, 2019·Stem Cells Translational Medicine·Stuart P Atkinson
Oct 12, 2019·International Journal of Hematology·Mai NanyaHideyo Hirai
Nov 15, 2019·Clinical Microbiology Reviews·Jean-Paul Latgé, Georgios Chamilos
Dec 2, 2018·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Monica B PaganoSimon J Stanworth
Mar 16, 2017·British Journal of Haematology·Kamille A WestSameer S Kadri
Aug 18, 2017·Transfusion·Michelle A LodermeierWilly A Flegel
Sep 16, 2017·Leukemia & Lymphoma·Victor Mulanovich, Dimitrios P Kontoyiannis
Apr 2, 2020·Academic Pathology·Kiran Manjee, Thomas J Gniadek
Aug 10, 2018·Frontiers in Microbiology·Qi Hui SamLouis Yi Ann Chai
Feb 15, 2018·Transfusion·Anand Padmanabhan
Sep 8, 2016·Journal of Fungi·Ethan R Stewart, George R Thompson
Dec 19, 2018·Journal of Fungi·Chris D LauruschkatJuergen Loeffler

Jun 7, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Jul 30, 2020·Journal of Clinical Apheresis·Gozde Akın KagızmanlıNese Yarali

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