Efficacy of transnasal nebulized surfactant on experimental otitis media with effusion in guinea pig

International Journal of Pediatric Otorhinolaryngology
Chul Ho JangIl Yong Park

Abstract

Recently experimental trials have demonstrated that nebulized natural surfactant is effective in the treatment of experimental otitis media with effusion (OME). Two methodologically incomplete studies using animal models of induced OME have reported that nebulized surfactant can improve Eustachian tube function. There have been no reports that investigated the efficacy of the nebulized surfactant for OME using analysis of tympanic membrane vibration. In this study, we evaluated the therapeutic effect of nebulized natural surfactant by investigation of tympanic membrane vibration. The guinea pigs (n=20) were divided into three groups. Four normal guinea pigs without any treatment were used as normal controls. Sixteen pigs were given experimental OME in both ear and then divided into two groups. The OME model of guinea pig was created by transbullar injection 10 microl of lipopolysaccharide in saline. Experimental group 1 (n=8) was nebulized phosphate buffered saline (PBS). Experimental group 2 (n=8) was nebulized natural bovine surfactant. The transnasal nebulization was repeated for 7 days in both experimental groups. On the 8th day, both experimental groups and normal control group were measured the tympanic membrane vibration...Continue Reading

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Citations

Jun 25, 2020·Journal of Clinical Pharmacology·Silvia FolignoDaniele De Luca

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