Efficacy of triple anti-platelet therapy including cilostazol in acute myocardial infarction patients undergoing drug-eluting stent implantation.

Korean Circulation Journal
Keun-Ho ParkJung Chaee Kang

Abstract

Triple anti-platelet therapy is known to prevent restenosis after drug-eluting stent (DES) implantation. However, there is little available data concerning the efficacy of triple anti-platelet therapy for acute myocardial infarction (AMI). We analyzed 528 consecutive patients with AMI undergoing DES implantation between Nov 2005 and Apr 2008. We compared clinical outcomes in the triple anti-platelet therapy (group I, n=413: cilostazol combined with aspirin and clopidogrel for at least one month) and dual antiplatelet therapy groups (group II, n=115: aspirin and clopidogrel). There were no significant differences in baseline characteristics. However, ST elevation myocardial infarction (STEMI) and use of TAXUS(R) stents were more common (70.9% vs. 55.7%, p=0.002; 83.5% vs. 73.0%, p=0.011) in Group I. Group I had lower incidences of cardiac death, 6-month target lesion revascularization (TLR), and major adverse cardiac and cerebrovascular events (MACCE) compared to Group II (1.7% vs. 5.7%, p=0.022; 5.7% vs. 11.5%, 0.035; 7.9% vs. 16.0%, p=0.011). On subgroup analysis, the incidence of 6-month TLR was lower among patients with American College of Cardiology/American Heart Association (ACC/AHA) B2 or C lesions and non-STEMI (6.0% vs...Continue Reading

References

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Citations

Jan 14, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Khurshid AhmedUNKNOWN Korea Acute Myocardial Infarction Registry Investigators
Jan 5, 2011·Journal of Cardiovascular Medicine·Natnicha KanlopNipon Chattipakorn
Oct 22, 2021·Journal of Clinical Pharmacology·Antonis A ManolisAntonis S Manolis

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Methods Mentioned

BETA
coronary artery bypass
coronary bypass

Software Mentioned

Statistical Package for Social Science ( SPSS
SPSS

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