PMID: 6968762Dec 1, 1980Paper

Efficacy of troleandomycin in outpatients with severe, corticosteroid-dependent asthma

The Journal of Allergy and Clinical Immunology
R S ZeigerD D Stevenson

Abstract

Sixteen severe, corticosteroid-dependent yet resistant outpatient asthmatics were treated with troleandomycin (TAO), a macrolide antibiotic, in an attempt to both induce a clinical remission and reduce methylprednisolone requirements. Within the first 2 wk of initiating TAO therapy, 50% of the patients experienced a greater than 20% increase in forced expiratory volume in 1 sec (FEV1) and 80% noted a greater than 20% increase in forced vital capacity between 25% and 75% (FVC 25%-75%). Maximal increases in FEV1 and FVC 25%-75% were noted in all patients within the first 6 wk on TAO and methylprednisolone. There was a concomitant clinical improvement in all patients. Corticosteroid-induced side effects, gastrointestinal tract discomfort, and elevated serum glutamic pyruvic transaminase (SGPT) were common yet generally transient during TAO and methylprednisolone therapy. After a 4- to 18-mo follow-up 15/16 patients were well-controlled on TAO and methylprednisolone. Methylprednisolone requirements were reduced at least four- to fivefold in most patients during TAO therapy. Normal morning serum cortisol levels were documented after varying intervals in most patients when both TAO (250 mg) and methylprednisolone (4 to 16 mg) could b...Continue Reading

References

Mar 1, 1977·The Journal of Allergy and Clinical Immunology·M WeinbergerC Chidsey
Nov 1, 1963·Southern Medical Journal·M F ENGEL
Apr 1, 1962·The American Journal of the Medical Sciences·M M ROBINSON

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Citations

Jan 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·W F EblingW J Jusko
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David ShitritMordechai R Kramer
Nov 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S R NimmagaddaS J Szefler
Nov 30, 1989·The New England Journal of Medicine·P J Barnes
Oct 1, 1992·Journal of Clinical Pharmacy and Therapeutics·H W Kelly
Jul 9, 2010·Clinical Microbiology Reviews·Soichiro Kanoh, Bruce K Rubin
Apr 4, 2003·American Journal of Respiratory and Critical Care Medicine·Susan G GerhardtJonathan B Orens
Jan 25, 2013·Journal of Asthma and Allergy·Anar MikailovMichael T Delvecchio
Jan 7, 2005·Clinical Pharmacokinetics·David CzockUlla Häussler
Apr 10, 2003·Chest·Alexander S Niven, Gregory Argyros
Jun 30, 2009·European Journal of Pharmacology·Boska HrvacićVesna Eraković Haber
Feb 22, 2008·Pharmacology & Therapeutics·Masaharu ShinkaiBruce K Rubin
Dec 14, 2004·The American Journal of Medicine·Bruce K Rubin
Jan 28, 2005·Respiratory Medicine·G FerraraL Richeldi
Jul 13, 2016·Immunology and Allergy Clinics of North America·Tara F Carr, Monica Kraft
Feb 8, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·H CorvolA Clement
Nov 11, 2005·Chronic Respiratory Disease·S C BellJ G McCormack
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C In 't VeenE H Bel
Jun 19, 2001·The Cochrane Database of Systematic Reviews·D J EvansD M Geddes
Nov 26, 2005·Expert Review of Anti-infective Therapy·Seamus Crowley, Jim J Egan
Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J Alvarez, S J Szefler
Oct 28, 2019·Archives of Disease in Childhood·Rama Lakshman
Sep 16, 2015·The Cochrane Database of Systematic Reviews·Kayleigh M KewGiovanni Ferrara
Jul 22, 1989·BMJ : British Medical Journal·R J Shiner, D M Geddes
Mar 1, 1987·Medical Toxicology·H J Zimmerman, J H Lewis
Jun 8, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·D N Payne, I M Balfour-Lynn
May 10, 1985·Journal of Chromatography·N Kucharczyk, F H Segelman
Jul 1, 1989·Current Problems in Pediatrics·D NeddenriepR J Lemen
Apr 6, 2004·Clinics in Liver Disease·Raja Mohi-ud-din, James H Lewis
Apr 9, 2001·Clinics in Liver Disease·J H Lewis, H J Zimmerman

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